FORDESIA

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    Komposisi:

    Donepezil HCL 5 mg.

    Bentuk sediaan:

    Tablet.

    Farmakologi:

    Meningkatkan acetylcholine melalui penghambatan hidrolisis acetylcholine oleh enzim acetylcholinesterase. Absorpsi baik, tidak dipengaruhi oleh makanan, Tmax: 3 – 4 jam T1/2: 70 jam, kadar mantap tercapai dalam 15 hari.

    Indikasi:

    Terapi demensia ringan atau sedang pada penyakit Alzheimer.

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    Dosis:

    5 mg atau 10 mg sekali sehari oral, malam hari sebelum tidur, dengan atau tanpa makan tanpa makanan.

    Kontraindikasi:

    Hipersensitif

    Peringatan dan Perhatian:

    Pemberian obat anesthesia seperti suksinilkoline dapat meningkatkan relaksasi otot, bersama obat jantung mengakibatkan bradikardia atau blok jantung. Berpotensi menimbulkan kejang menyeluruh sekresi asam lambung meningkat akibat aktivitas kolinergik, beresiko tinggi menderita ulkus. Hati-hati diberikan pada pasien dengan riwayat asma/paru obstruktif. Tidak aman bagi ibu hamil, ibu menyusui (belum diketahui ekskresinya di air susu ibu dan anak).

    Efek Samping:

    Paling sering adalah efek kolinomimetik yaitu nausea, diare. Insomia, muntah, kram otot, lemah dan anoreksia, namun umumnya ringan dan sementara, menghilang setelah terapi donepezil dihentikan.

     

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    FORDESIA

     

    Composition:

    Donepezil HCl

    Presentation:

    Coated tablet 5 mg/Doos : 3 strip @ 10 tablets.

    Pharmacology:

    Donepezil HCl inhibits acetylcholinesterase specifically and reversible. On oral administration, plasma concentration reached in 3-4 hours after the dose administration. 95% Donepezil HCl bounded to plasma protein, 57% excreted into urine and 14.5% into feses. In patient with dementia Alzheimer who involved in clinical study, there is significant relationship between donepezil hcl plasma level, inhibition of AChE and improvement in ADAS-cog, a sensitive scale in memory test.

    Indications:

    Symptomatic therapy of mild or moderate dementia in Alzheimer disease.

    Contraindications:

    Patient that sensitive to donepezil hydrochloride, piperidine derivatives or another components in this product.

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    Dosage:

    Loading dose 5 mg/day, once a day. FORDESIA must be consumed orally at night, before sleep. This dose is maintained at least for a month to reach steady-state concentration. After that, dose can be increased to 10 mg/day, once a day. Dose more than 10 mg/day, hasn’t been studied. If the therapy is stopped, FORDESIA effect decrease slowly. No need adjustment dose for patient with kidney and liver disorders

    Warning and Precautions:

    It is not recommended for children, lactation and pregnant women because of limited safety data

    Adverse events:

    The most frequently side effect in donepezil hcl therapy is mild diarrhea and muscle cramps

    Drugs Interaction:

    -

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