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    Komposisi:

    Ranitidine HCl setara dengan Ranitidine 150 mg

    Bentuk sediaan:

    Tablet salut selaput

    Farmakologi:

    Ranitidine adalah suatu histamin antagonis reseptor H2 yang menghambat kerja histamin secara kompetitif pada reseptor H2 dan mengurangi sekresi asam lambung. Pada pemberian oral Ranitidine diabsorpsi 50% setelah pemberian oral. Konsentrasi puncak plasma dicapai 2 – 3 jam setelah pemberian dosis 150 mg. Absorpsi tidak dipengaruhi secara signifikan oleh makanan dan antasida. Waktu paruh 21/2 – 3 jam pada pemberian oral. Ranitidine diekskresi melalui urin.

    Indikasi:

    Pengobatan jangka pendek tukak usus 12 jari aktif, tukak lambung aktif, mengurangi gejala refluks esofagitis. Terapi pemeliharaan setelah penyembuhan tukak usus 12 jari, tukak lambung. Pengobatan keadaan hipersekresi patologis (misal : sindroma Zollinger Ellison dan mastositosis sistemik).

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    Dosis:

    Tukak usus 12 jari aktif:

    150 mg 2 kali sehari (pagi dan malam) atau 300 mg sekali sehari sesudah makan malam atau sebelum tidur, selama 4 – 8 minggu.

    Tukak lambung aktif: 150 mg 2 kali sehari (pagi dan malam) selama 2 minggu.

    Terapi pemeliharaan pada penyembuhan tukak 12 jari dan tukak lambung:

    Dewasa : 150 mg, malam hari sebelum tidur.

    Keadaan hipersekresi patologis (Zollinger Ellison, mastositosis sistemik):

    Dewasa : 150 mg, 2 kali sehari dengan lama pengobatan ditentukan oleh dokter berdasarkan gejala klinik yang ada.

    Dosis dapat ditingkatkan sesuai dengan kebutuhan masing-masing penderita. Dosis hingga 6 g sehari dapat diberikan pada penyakit yang berat.

    Refluks gastroesofagitis:

    Dewasa : 150 mg, 2 kali sehari.

    Esofagitis erosif:

    Dewasa : 150 mg, 4 kali sehari.

    Pemeliharaan dan penyembuhan esofagitis erosif:

    Dewasa : 150 mg, 2 kali sehari.

    Dosis pada penderita gangguan fungsi ginjal:

    Bila bersihan kreatinin < 50 ml / menit : 150 mg / 24 jam. Bila perlu dosis dapat ditingkatkan secara hati-hati setiap 12 jam atau kurang tergantung kondisi penderita.

    Hemodialisis menurunkan kadar Ranitidine yang terdistribusi.

    Kontraindikasi:

    Hipersensitif terhadap ranitidine

    Interaksi Obat:

    Ranitidine tidak menghambat kerja dari sitokrom P 450 dalam hati. Pemberian bersama warfarin dapat meningkatkan atau menurunkan waktu protrombin.

    Efek Samping:

    Sakit kepala

    Susunan saraf pusat, jarang terjadi : malaise, pusing, mengantuk, insomnia, vertigo, agitasi, depresi, halusinasi.

    Kardiovaskular, jarang dilaporkan : aritmia seperti takikardia, bradikardia, atrioventricular block, premature ventricular beats.

    Gastrointestinal : konstipasi, diare, mual, muntah, nyeri perut. Jarang dilaporkan : pankreatitis.

    Muskuloskeletal, jarang dilaporkan : artralgia dan mialgia.

    Hematologik : leukopenia, granulositopenia, pansitopenia, trombositopenia, anemia aplastik pernah dilaporkan.

    Endokrin : ginekomastia, impoten dan hilangnya libido pernah dilaporkan pada penderita pria.

    Kulit, jarang dilaporkan : ruam, eritema multiforme, alopesia.

    Lain-lain, kasus hipersensitifitas yang jarang (contoh : bronkospasma, demam, eosinofilia), anafilaksis, edema angioneurotik, sedikit peningkatan kadar dalam kreatinin serum.

     

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    TITAN

     

    Composition:

    Ranitidine HCl equivalent to Ranitidine 150 mg

    Presentation:

    Film coated tablet

    Pharmacology:

    Ranitidine is a histamine H2 receptor antagonist which inhibits the action of histamine competitively on H2 receptors and reduces gastric acid secretion. Oral administration of Ranitidine is absorbed 50% after oral administration. The peak plasma concentration is achieved 2-3 hours after the administration of 150 mg. Absorption is not significantly affected by food and antacids. Half-life of ranitidine is 2,5 - 3 hours on oral administration. Ranitidine is excreted through urine.

    Indications:

    Short-term treatment of active duodenal ulcer, active gastric ulcer, reduces symptoms of reflux esophagitis. Maintenance therapy after duodenal ulcers, gastric ulcers. Treatment of pathological hypersecretion (eg. Zollinger Ellison syndrome and systemic mastocytosis).

    Contraindications:

    Ranitidine hypersensitivity

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    Dosage:

    Active duodenal ulcer: 150 mg twice a day (morning and night) or 300 mg once a day after dinner or before bed, for 4-8 weeks. Active gastric ulcer: 150 mg 2 times a day (morning and night) for 2 weeks. Maintenance therapy for healing 12-finger ulcers and gastric ulcers: Adults: 150 mg, at night before going to bed. Pathological hypersecretion (Zollinger Ellison, systemic mastocytosis): Adults: 150 mg, 2 times a day with the duration of treatment determined by the doctor based on existing clinical symptoms. The dosage can be increased according to the needs of each patient. Doses of up to 6 g a day can be given to severe diseases. Gastroesophagitis reflux: Adults: 150 mg, 2 times a day. Erosive esophagitis: Adults: 150 mg, 4 times a day. Maintenance and healing of erosive esophagitis: Adults: 150 mg, 2 times a day. Dosage in patients with kidney function disorders: If creatinine clearance <50 ml / minute: 150 mg / 24 hours. If necessary, the dosage can be increased carefully every 12 hours or less depending on the patient's condition. Hemodialysis decreases distributed levels of Ranitidine.

    Warning and Precautions:

    Ranitidine does not inhibit the action of cytochrome P 450 in the liver. Giving with warfarin can increase or decrease prothrombin time.

    Adverse events:

    Headache Central nervous system, rarely: malaise, dizziness, drowsiness, insomnia, vertigo, agitation, depression, hallucinations. Cardiovascular, rarely reported: arrhythmias such as tachycardia, bradycardia, atrioventricular block, premature ventricular beats. Gastrointestinal: constipation, diarrhea, nausea, vomiting, abdominal pain. Rarely reported: pancreatitis. Musculoskeletal, rarely reported: arthralgia and myalgia. Hematologic: leukopenia, granulocytopenia, pancytopenia, thrombocytopenia, aplastic anemia have been reported. Endocrine: gynecomastia, impotence and loss of libido have been reported in male sufferers. Skin, rarely reported: rash, erythema multiforme, alopecia. Other, rare cases of hypersensitivity (eg bronchospasm, fever, eosinophilia), anaphylaxis, angioneurotic edema, slight increase in serum creatinine levels.

    Drugs Interaction:

    Ranitidine does not inhibit the action of cytochrome P 450 in the liver. Giving with warfarin can increase or decrease prothrombin time.

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