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    Komposisi:

    Ethambutol HCl

    Bentuk sediaan:

    Kaplet salut selaput

    Farmakologi:

    menghambat pembentukan metabolit sehingga mengganggu metabolisme sel dan replikasi bakteri dan mematikan sel bakteri

    Indikasi:

    Antituberkulosa. Penggunaan bukan sebagai obat tunggal, tetapi dikombinasi dengan paling sedikit satu macam obat antituberkulosa, misalnya rifampicin, INH.

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    Dosis:

    - Dosis lazim : 15 - 25 mg/kg BB sehari sebagai dosis tunggal.

    - Pasien yang belum pernah mendapat pengobatan antituberkulosa sebelumnya, dosis ethambutol adalah: 15 mg/kg/BB/hari dalam dosis tunggal, sekali setiap 24 jam.

    Kontraindikasi:

    Hipersensitif terhadap ethambutol Pasien dengan neuritis optik

    Peringatan dan Perhatian:

    - Pemeriksaan mata harus dilakukan sebelum pengobatan.

    - Tidak dianjurkan pada anak di bawah 13 tahun.

    - Penggunaan ethambutol harus dihentikan dengan segera apabila terjadi gangguan penglihatan

    Efek Samping:

    - Toksisitas okuler yang tergantung pada dosis dan lamanya pengobatan.

    - Bisa terjadi neuritis retrobulbar bilateral dengan gejala terjadi penurunan ketajaman penglihatan, kehilangan kemampuan membedakan warna, penyempitan lapangan pandang, skotomata sentral dan perifer.

     

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    Composition:

    Ethambutol hydrochloride.

    Presentation:

    Film coated caplet 500 mg : box contains 10 strips x 10 caplets.

    Pharmacology:

    Inhibits the synthesis of one or more metabolites in susceptible bacteria resulting in impairment of cellular metabolism, arrest of multiplication, and cell death.

    Indications:

    Antituberculosis drug. It should not be used as the sole antituberculous drug, but should be used in conjunction with at least one other antituberculous drug, for example rifampicin, INH.

    Contraindications:

    - Patients who are hypersensitive to ethambutol. - Patients with optic neuritis.

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    Dosage:

    - Common dosage: 15-25 mg/kg daily as a single dose. - Patients who have never received antituberculosis treatment before, the ethambutol dose is: 15 mg/kg/day in a single dose, once every 24 hours.

    Warning and Precautions:

    - Eye examination must be done before treatment. - Not recommended for children under 13 years. - The use of ethambutol must be stopped immediately if there is a visual impairment.

    Adverse events:

    - Ocular toxicity depends on the dose and duration of treatment. - Bilateral retrobulbar neuritis can occur with symptoms of decreased visual acuity, loss of ability to distinguish colors, narrowing of the field of view, central and peripheral scotomata.

    Drugs Interaction:

    The oral absorption of ethambutol may be reduced by aluminum hydroxide containing antacid products. It is recommended to avoid concurrent administration of ethambutol with aluminum hydroxide containing antacids for at least 4 hours following ethambutol administration.

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