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    Komposisi:

    Cefepime

    Bentuk sediaan:

    Vial 1 g

    Farmakologi:

    Cephalosporin generasi 4 parenteral. Bekerja menghambat Penicillin Binding Protein bakteri lalu menghambat sintesis dinding sel bakteri sehigga bersifat bakterisidal. Memiliki aktivitas anti-Pseudomonas. Eliminasi melalui ginjal, waktu paruh eliminasi 2 jam.

    Indikasi:

    Pneumonia, demam neutropenia, infeksi saluran kemih berkomplikasi (pielonefritis), infeksi kulit dan struktur kulit, infeksi intraabdomen.

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    Dosis:

    Dewasa : 0,5 - 2 g setiap 8 - 12 jam.

    Anak: 50 mg/kgBB/dosis, diberikan setiap 8 - 12 jam.

    Kontraindikasi:

    Hipersensitif

    Peringatan dan Perhatian:

    Hati-hati bila terdapat riwayat hipersensitivitas, pada pasien dengan gangguan fungsi ginjal diperlukan penyesuaian dosis, dapat menyebabkan kolitis pseudomembranosa, kategori kehamilan B, keamanan pada bayi di bawah usia 2 bulan belum diketahui.

    Efek Samping:

    Kejang, ensefalopati, hipersensitivitas, mual, muntah, diare, kolitis, sakit kepala, perubahan nilai laboratorium.

     

     

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    VIPIME

     

    Composition:

    Cefepime

    Presentation:

    Vial 1 g

    Pharmacology:

    Parenteral 4th generation cephalosporin. Working inhibits Penicillin Binding Bacterial proteins then inhibit bacterial cell wall synthesis so they are bactericidal. Has anti-Pseudomonas activity. Elimination through the kidneys, elimination half-life of 2 hours.

    Indications:

    Pneumonia, neutropenic fever, complicated urinary tract infections (pyelonephritis), skin infections and skin structure, intra-abdominal infections.

    Contraindications:

    Hypersensitivity

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    Dosage:

    Adults: 0.5 - 2 g every 8 - 12 hours. Children: 50 mg / kgBB / dose, given every 8-12 hours.

    Warning and Precautions:

    Be careful if there is a history of hypersensitivity, in patients with impaired kidney function dose adjustments are needed, can cause pseudomembranous colitis, category B pregnancy, safety in infants under the age of 2 months is unknown.

    Adverse events:

    Seizures, encephalopathy, hypersensitivity, nausea, vomiting, diarrhea, colitis, headaches, changes in laboratory values.

    Drugs Interaction:

    Monitor kidney function carefully with Cefepime along with high-dose aminoglycosides because it increases the risk of nephrotoxicity and ototoxicity from aminoglycoside antibiotics. Nephrotoxicity has also been reported in concurrent administration of potent cephalosporins and diuretics like Furosemide.

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