CLAVAMOX

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    Komposisi:

    Amoxicillin + Clavulanate

    Bentuk sediaan:

    Tablet 500 mg,

    Sirup 125 mg / 5 mL.

    Farmakologi:

    Kombinasi antibotik beta-laktam dengan inhibitor beta-laktamase. Bekerja menghambat Penicillin Binding Protein bakteri lalu menghambat sintesis dinding sel bakteri sehigga bersifat bakterisidal. Bioavailablitas oral 90%. Eliminasi melalui ginjal. Waktu paruh eliminasi 1,5 jam.

    Indikasi:

    Oral: Infeksi saluran napas atas, infeksi saluran napas bawah, infeksi saluran urogenital, infeksi kulit dan jaringan lunak, infeksi tulang dan sendi, infeksi gigi, sepsis.

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    Dosis:

    Dewasa dan anak di atas 12 tahun, 250 - 500 mg 3 kali sehari.

    Anak 6 - 12 tahun 250 mg 3 kali sehari

    Anak 1 - 6 tahun 125 mg 3 kali sehari, anak di bawah 1 tahun 50 mg 3 kali sehari.

    Kontraindikasi:

    Hipersensitif

    Peringatan dan Perhatian:

    Dapat terjadi reaksi hipersensitivitas, kategori kehamilan B, hati-hati penggunaan pada pasien gangguan hati berat.

    Efek Samping:

    Diare, mual, muntah, ruam, urtikaria, sakit kepala, kolitis pseudomembranosa, reaksi hipersensitivitas, perubahan nilai laboratorium dan flebitis.

     

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    CLAVAMOX

     

    Composition:

    Each CLAVAMOX 500 film coated caplet contains: Amoxicillin Trihydrate is equivalent to Amoxicillin 500 mg Potassium Clavulanate is equivalent to Clavulanic acid 125 mg.

    Presentation:

    CLAVAMOX 500 caplets: Box of 3 strips of x 10 caplets.

    Pharmacology:

    Beta-lactam antibiotic combination with beta-lactamase inhibitors. Works inhibits Penicillin Binding Bacterial proteins then inhibit bacterial cell wall synthesis so they are bactericidal. Oral bioavailability of 90%. Elimination through the kidneys. Elimination half-life of 1.5 hours.

    Indications:

    Oral: Upper airway infection, lower airway infection, urogenital tract infection, skin and soft tissue infections, bone and joint infections, dental infections, sepsis.

    Contraindications:

    Hypersensitivity.

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    Dosage:

    Adults and children over 12 years: CLAVAMOX 500 caplets 3 times a day.

    Warning and Precautions:

    Hypersensitivity reactions, category B pregnancy, careful use in patients with severe liver disorders can occur.

    Adverse events:

    Diarrhea, nausea, vomiting, rash, urticaria, headache, pseudomembranous colitis, hypersensitivity reactions, changes in laboratory values and phlebitis.

    Drugs Interaction:

    - Can reduce the effectiveness of oral contraceptives. - Can increase bleeding time and blood clotting time in patients receiving anticoagulant treatment

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