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CLAVAMOX

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    Komposisi:

    Tiap kaplet salut selaput CLAVAMOX 500 mengandung: 
    Amoxicillin Trihydrate setara dengan Amoxicillin 500 mg 
    Potassium Clavulanate setara dengan Clavulanic acid 125 mg

     

    Tiap 5 mL sirup CLAVAMOX mengandung : 
    Amoxicillin Trihydrate setara dengan Amoxicillin 125 mg 
    Potassium Clavulanate setara dengan Clavulanic acid 31,25 mg

    Bentuk sediaan:

    CLAVAMOX 500 kaplet : Dus berisi 3 strip x 10 kaplet.
    CLAVAMOX 125 sirup kering : Dus isi 1 botol 60 mL

    Farmakologi:

    Kombinasi antibotik beta-laktam dengan inhibitor beta-laktamase. Bekerja menghambat Penicillin Binding Protein bakteri lalu menghambat sintesis dinding sel bakteri sehigga bersifat bakterisidal. Bioavailablitas oral 90%. Eliminasi melalui ginjal. Waktu paruh eliminasi 1,5 jam.

    Indikasi:

    Oral: Infeksi saluran napas atas, infeksi saluran napas bawah, infeksi saluran urogenital, infeksi kulit dan jaringan lunak, infeksi tulang dan sendi, infeksi gigi, sepsis.

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    Dosis:

    Dewasa dan anak di atas 12 tahun:  CLAVAMOX 500 kaplet 3 kali sehari.

    Sirup: 
    Anak < 1 tahun : 2 mL, 3 kali sehari. 
    Anak 1 - 6 tahun (10 - 18 kg) : 5 mL, 3 kali sehari.
    Anak > 6 tahun (18 - 40 kg) : 10 mL, 3 kali sehari. 
    Dosis yang direkomendasikan untuk anak 25 mg/kg/hari dalam dosis terbagi setiap 8 jam. (Setiap 25 mg sirup CLAVAMOX mengandung amoxicillin 20 mg dan clavulanic acid 5 mg)

    Kontraindikasi:

    Hipersensitif

    Peringatan dan Perhatian:

    Dapat terjadi reaksi hipersensitivitas, kategori kehamilan B, hati-hati penggunaan pada pasien gangguan hati berat. Untuk melarutkan CLAVAMOX sirup kering, tambahkan air 58 ml dan kocok balk - baik sampai semua bubuknya larut. Setelah dicampur, suspensi ini perlu disimpan di tempat kering serta sejuk (2 - 8°C) dan tidak boleh digunakan setelah 7 hari.

    Efek Samping:

    Diare, mual, muntah, ruam, urtikaria, sakit kepala, kolitis pseudomembranosa, reaksi hipersensitivitas, perubahan nilai laboratorium dan flebitis.

    Interaksi Obat:

    - Dapat menurunkan efektivitas kontrasepsi oral.

    - Dapat meningkatkan waktu perdarahan dan waktu pembekuan darah pada penderita yang mendapat pengobatan antikoagulan.

     

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    CLAVAMOX

     

    Composition:

    Each CLAVAMOX 500 film coated caplet contains: Amoxicillin Trihydrate is equivalent to Amoxicillin 500 mg Potassium Clavulanate is equivalent to Clavulanic acid 125 mg Each 5 mL CLAVAMOX syrup contains: Amoxicillin Trihydrate is equivalent to Amoxicillin 125 mg Potassium Clavulanate is equivalent to Clavulanic acid 31.25 mg

    Presentation:

    CLAVAMOX 500 caplets: Box of 3 strips of x 10 caplets. CLAVAMOX 125 dry syrup: Box of 60 mL bottle.

    Pharmacology:

    Beta-lactam antibiotic combination with beta-lactamase inhibitors. Works inhibits Penicillin Binding Bacterial proteins then inhibit bacterial cell wall synthesis so they are bactericidal. Oral bioavailability of 90%. Elimination through the kidneys. Elimination half-life of 1.5 hours.

    Indications:

    Oral: Upper airway infection, lower airway infection, urogenital tract infection, skin and soft tissue infections, bone and joint infections, dental infections, sepsis.

    Contraindications:

    Hypersensitivity.

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    Dosage:

    Film coated caplet:
    Adults and children over 12 years: CLAVAMOX 500 caplet 3 times a day.

    Syrup:
    Children < 1 year : 2 mL, 3 times a day.
    Children 1 - 6 years (10 - 18 kg): 5 mL, 3 times a day.
    Children > 6 years (18 - 40 kg): 10 mL, 3 times a day.
    The recommended dosage for children is 25 mg / kg / day in divided doses every 8 hours. (Every 25 mg of CLAVAMOX syrup contains 20 mg amoxicillin and 5 mg clavulanic acid)

    Warning and Precautions:

    Hypersensitivity reactions, category B pregnancy, careful use in patients with severe liver disorders can occur. To dispense CLAVAMOX dry syrup 60 ml, add 58 ml of water and shake well until all powder is well dispersed. After mixing, the suspension may be kept in a cool dry place (2 - 8°C). Discarded after 7 days.

    Adverse events:

    Diarrhea, nausea, vomiting, rash, urticaria, headache, pseudomembranous colitis, hypersensitivity reactions, changes in laboratory values and phlebitis.

    Drugs Interaction:

    - Can reduce the effectiveness of oral contraceptives. - Can increase bleeding time and blood clotting time in patients receiving anticoagulant treatment

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