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    Komposisi:

    Metformin 500 mg.

    Bentuk sediaan:

    Tablet 500 mg. 1 kotak isi 10 strip x 10 tablet.

    Farmakologi:

    Mekanisme utama metformin dalam mengontrol kadar gula darah adalah dengan cara menghambat produksi glukosa (glukoneogenesis) di hati.

    Indikasi:

    DM tipe 2 ( NIDDM ) yang kadar gula darahnya tidak terkontrol dengan diit dan aktivitas fisik.

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    Dosis:

    Dosis awal : 2x500 mg/hari

    Titrasi : dapat ditingktan 500 mg/minggu setiap 2 minggu.

    Dosis maksimum : 2000 mg dalam dosis terbagi. Diberikan bersama makanan.

    Kontraindikasi:

    Hipersensitif terhadap metformin, koma diabetik dan ketoasidosis, gangguan fungsi ginjal.

    Penyakit hati kronis, gagal jantung dan infark miokardium, alkoholisme, riwayat atau keadaan yang berkaitan dengan asidosis laktat seperti syok atau insufisiensi pulmonal dan keadaan yang berhubungan dengan hipoksemia.

    Kehamilan dan menyusui.

    Peringatan dan Perhatian:

    Hati-hati pada gangguan fungsi ginjal.

    Tidak dianjurkan penggunaan pada kondisi dimana menyebabkan dehidrasi atau pada penderita yang baru sembuh dari infeksi serius atau trauma.

    Dianjurkan pemeriksaan berkala kadar B12 pada penggunaan jangka panjang.

    Hati-hati pemberian pada pasien usia lanjut yang mempunyai gangguan fungsi ginjal.

    Tidak direkomendasikan penggunaan pada anak-anak.

    Efek Samping:

    Anoreksia, mual, muntah, diare.

     

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    DIABIT

     

    Composition:

    Metformin 500 mg.

    Presentation:

    Tablet 500 mg : Box contains 10 strips x 10 tablets.

    Pharmacology:

    The main mechanism of metformin in controlling blood sugar levels is by inhibiting glucose production (gluconeogenesis) in the liver.

    Indications:

    Treatment of type 2 diabetes mellitus (NIDDM), when dietary management and exercise alone does not result in adequate glycaemic control.

    Contraindications:

    - Hypersensitivity to metformin, diabetic coma and ketoacidosis, impaired renal function. - Chronic liver disease, heart failure and myocardial infarction, alcoholism, history or circumstances related to lactic acidosis such as shock or pulmonary insufficiency and conditions associated with hypoxemia. - Pregnancy and breastfeeding.

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    Dosage:

    Initial dose: 2 x 500 mg / day Titration: can be increased by 500 mg / week every 2 weeks. Maximum dose: 3000 mg in divided doses. Given with food.

    Warning and Precautions:

    - Be careful of kidney function disorders. - Not recommended for use in conditions that cause dehydration or for patients who have just recovered from a serious infection or trauma. - Periodic B12 levels examination are recommended for long-term use. - Elderly patients who have impaired kidney function. - Not recommended for use in children.

    Adverse events:

    Anorexia, nausea, vomiting, diarrhea.

    Drugs Interaction:

    - Possible interactions between Metformin and anticoagulants. In this case, an anticoagulant dose adjustment may be needed. - Reduced clearance of metformin has been reported during cimetidine therapy, so a dose reduction should be considered.

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