ENYSTIN

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    Komposisi:

    Nystatin

    Bentuk sediaan:

    Suspensi 100.000 unit / 1 mL, botol 12 mL, dengan pipet yang dikalibrasi untuk 0,5 mL.

    Farmakologi:

    Nystatin sangat sedikit diserap dari saluran cerna. Sebagian besar nystatin yang dikonsumsi secara oral akan diekskresi lewat tinja dalam bentuk tidak berubah. Nystatin bekerja dengan cara berikatan pada sterol di membran sel Candida yang rentan berakibat pada perubahan permeabilitas membran sel dan kebocoran dari komponen intraseluler.

    Indikasi:

    Pengobatan candidiasis rongga mulut.

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    Dosis:

    Bayi, anak dan dewasa: Dosis yang direkomendasikan adalah 1 mL (100.000 unit) empat kali sehari. Dosis nystatin sebaiknya dilanjutkan sampai 48 jam setelah gejala hilang.

    Kontraindikasi:

    Hipersensitif

    Peringatan dan Perhatian:

    Enystin tidak bisa digunakan untuk mengobati infeksi jamur sistemik. Jika muncul iritasi atau sensitisasi, pengobatan sebaiknya dihentikan.

    Efek Samping:

    Dosis oral dalam jumlah besar kadang-kadang menimbulkan diare, gangguan saluran cerna, mual dan muntah. Ruam, termasuk urtikaria telah dilaporkan jarang terjadi. Sindrom Stevens-Johnson telah dilaporkan sangat jarang terjadi.

     

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    ENYSTIN

     

    Composition:

    Nystatin

    Presentation:

    Suspension of 100,000 units / 1 mL in a 12 mL bottle, with a dropper calibrated for 0.5 mL.

    Pharmacology:

    Nystatin is very little absorbed from the digestive tract. Most of the nystatin consumed orally will be excreted through feces in an unchanged form. Nystatin works by binding to the sterols in the Candida cell membrane which is susceptible resulting in changes in cell membrane permeability and leakage from the intracellular component.

    Indications:

    Treatment of candidiasis of the oral cavity.

    Contraindications:

    Hypersensitivity.

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    Dosage:

    Infants, children and adults: The recommended dose is 1 mL (100,000 units) four times a day. The dose of nystatin should be continued for up to 48 hours after the symptoms disappear.

    Warning and Precautions:

    Enystin cannot be used to treat systemic fungal infections. If irritation or sensitization appears, treatment should be stopped.

    Adverse events:

    Large amounts of oral doses sometimes cause diarrhea, gastrointestinal disorders, nausea and vomiting. Rashes, including urticaria have been reported to be rare. Stevens-Johnson syndrome has been reported to be very rare.

    Drugs Interaction:

    -

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