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    Komposisi:

    Captopril 12,5 , 25 dan 50 mg

    Bentuk sediaan:

    Tablet

    Farmakologi:

    Captopril merupakan penghambat yang kompetitif terhadap enzim pengubah angiotensin-I menjadi angiotensin-II / angiotensin converting enzyme (ACE). Captopril mencegah terjadinya perubahan dari angiotensin-I menjadi angiotensin II, salah satu senyawa yang dapat menaikkan tekanan darah.

    Indikasi:

    Pengobatan hipertensi ringan sampai sedang. Pada hipertensi berat digunakan bila terapi standar tidak efektif atau tidak dapat digunakan. Pengobatan gagal jantung kongesti, digunakan bersama dengan diuretik dan bila mungkin dengan digitalis.

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    Dosis:

    Hipertensi ringan sampai sedang.

    Dosis awal 12,5 mg, 2 kali sehari. Dosis pemeliharaan 25 mg, 2 kali sehari, yang dapat ditingkatkan selang 2 – 4 minggu. Dosis maksimum 50 mg 2 kali sehari.

    Hipertensi berat.

    Dosis awal 12,5 mg, 2 kali sehari. Dosis dapat ditingkatkan bertahap menjadi maksimum 50 mg , 3 kali sehari. Dosis captopril jangan melebihi 150 mg sehari.

    Gagal jantung.

    Dosis awal 6,25 mg atau 12,5 mg dapat meminimkan efek hipotensif sementara. Dosis pemeliharaan 25 mg, 2 – 3 kali sehari, dapat ditingkatkan bertahap dengan selang paling sedikit 2 minggu. Dosis maksimum 150 mg sehari.

    Kontraindikasi:

    Penderita yang hipersensitif terhadap captopril atau penghambat ACE lainnya

    Wanita hamil atau yang berpotensi hamil, wanita menyusui.

    Gagal ginjal, stenosis aorta.

    Peringatan dan Perhatian:

    Pada penderita yang mengalami tanda-tanda infeksi akut (demam, faringitis), pemberian captopril harus dihentikan karena merupakan petunjuk adanya neutropenia. Dapat terjadi sindroma nefrotik serta glomerulopati membran pada penderita dengan hipertensi berat. Karena proteinuria umumnya terjadi pada waktu 8 bulan pengobatan, maka penderita sebaiknya melakukan pemeriksaan protein urin sebelum dan setiap bulan selama 8 bulan pertama pengobatan. Pemberian pada anak-anak masih belum diketahui keamanan dan efektivitasnya.Apabila pada pemakaian obat ini ternyata wanita itu hamil, maka pemberian obat harus dihentikan dengan segera.

    Efek Samping:

    • Proteinuria, peningkatan ureum darah dan kreatinin.

    • Idiosinkratik, rashes, terutama pruritus.

    • Neutropenia, anemia, trombositopenia.

    • Hipotensi, batuk

     

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    Composition:

    Captopril 12.5 mg, 25 mg and 50 mg.

    Presentation:

    Box of 5 strips x 10 tablets.

    Pharmacology:

    Captopril is a competitive inhibitor of the angiotensin-I conversion enzyme to angiotensin-II / angiotensin-converting enzyme (ACE). Captopril prevents changes from angiotensin-I to angiotensin-II, one of the compounds that can raise blood pressure. Captopril and its metabolites are excreted mainly through urine. Elimination of the captopril half-life increases with decreased kidney function where the speed of elimination is related to creatinine clearance.

    Indications:

    - Treatment of mild to moderate hypertension. It is used in severe hypertension when standard therapy is ineffective or can not be used. - Treatment of congestive heart failure, used together with diuretics and if possible with digitalis.

    Contraindications:

    -• Hypersensitivity to captopril or other ACE inhibitors (for example, patients experience angioedema during treatment with other ACE inhibitors). • Pregnant women or those who are potentially pregnant. • Breastfeeding women. • Kidney failure. • Aortic stenosis.

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    Dosage:

    • Mild to moderate hypertension: Initial dose of 12.5 mg, 2 times a day. Maintenance dose of 25 mg 2 times a day, which can be increased in 2 - 4 weeks intervals, to obtain a satisfactory response. The maximum dose is 50 mg, 2 times a day. Thiazide diuretics can be added if a satisfactory response has not been obtained. Diuretic doses can be increased in 1-2 weeks until an optimum response or maximum dose is obtained. • Severe hypertension: Initial dose of 12.5 mg, 2 times a day. The dosage can be increased gradually to a maximum of 50 mg, 3 times a day. Captopril should be used with antihypertensive drugs with dosage adjustments. Don't use Captopril with the dosage exceed 150 mg a day. • Heart failure. Captopril is used if therapy with diuretics is not sufficient to control symptoms. Initial dose : 6.25 mg or 12.5 mg can minimize the temporary hypotensive effect. Maintenance dose of 25 mg, 2-3 times a day, can gradually be increased at intervals of at least 2 weeks. Maximum dose of 150 mg daily. • Elderly. It is recommended to use a low initial dose, given the possibility of decreased kidney function or other organs in elderly patients. • Children. The initial dose is 0.3 mg/kg body weight to a maximum of 6 mg/kg body weight per day in 2-3 doses, depending response.

    Warning and Precautions:

    - Neutropenia/agranulocytosis, anemia and thrombocytopenia can occur in the use of captopril. - Careful use in patients with vascular collagen disease who receive immunosuppressant therapy, treatment with allopurinol or procainamide, children, people with kidney disease. - Nephrotic syndrome and membrane glomerulopathy can occur in patients with severe hypertension.

    Adverse events:

    • Proteinuria, increased blood urea and creatinine. • Idiosyncratic, rashes, especially pruritus. • Neutropenia, anemia, thrombocytopenia. • Hypotension

    Drugs Interaction:

    • Immunosuppressant drugs can cause blood dyscrasias in captopril users with kidney failure. • Potassium supplements or diuretic drugs containing potassium, there can be a significant increase in serum potassium. • Probenecid, can reduce kidney clearance from captopril. • Non-steroidal anti-inflammatory drugs, can reduce the effectiveness of antihypertensive agents. • Diuretic drugs increase the antihypertensive effect of captopril. • Captopril is reported to work synergistically with peripheral vasodilators such as minoxidil.

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