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    Komposisi:

    Amlodipine besylate 5 dan 10 mg

    Bentuk sediaan:

    Tablet

    Farmakologi:

    Amlodipine merupakan antagonis calcium golongan dihydropirydine (antagonis ion kalsium) yang menghambat influks ion calcium melalui membran ke dalam otot polos vaskular dan otot jantung sehingga mempengaruhi kontraksi otot polos vaskuler dan otot jantung. Amlodipine menghambat influks ion calcium secara selektif, di mana sebagian besar mempunyai efek pada sel otot polos vaskular dibandingkan sel otot jantung

    Indikasi:

    Hipertensi, angina stabil kronik dan vasospastik

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    Dosis:

    Dosis awal 5 mg/hari, maksimal 10 mg/hari. Titrasi dosis dilakukan tiap 7-14 hari

    Kontraindikasi:

    Pasien yang hipersensitif terhadap amlodipine dan golongan dihydropirydine lainnya

    Peringatan dan Perhatian:

    Pengawasan ketat pada pasien gangguan fungsi hati dan gagal jantung kongestif

    Efek Samping:

    Umum yang sering timbul: edema dan sakit kepala

     

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    Composition:

    Amlodipine besylate 5 dan10 mg.

    Presentation:

    Tablet.

    Pharmacology:

    Amlodipine is a calcium antagonist, class of dihydropirydine (calcium ion antagonist) that inhibits calcium ion influx through the membrane into vascular smooth muscle and heart muscle which affects contraction of vascular smooth muscle and heart muscle. Amlodipine inhibits selective ion calcium influx, where most have effects on vascular smooth muscle cells compared to heart muscle cells

    Indications:

    Hypertension, chronic stable angina and vasospastic.

    Contraindications:

    Patients who are hypersensitive to amlodipine and other dihydropyridine groups.

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    Dosage:

    The initial dose is 5 mg/day, maximum dose is 10 mg/day. Titration dose is done every 7-14 days..

    Warning and Precautions:

    Strict supervision in patients with liver function disorders and congestive heart failure.

    Adverse events:

    Common that often arises: edema and headache.

    Drugs Interaction:

    -

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