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PIRACETAM OGB HJ

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    Komposisi:

    Piracetam 1 g/5 mL dan 3 g/15 mL.

    Piracetam 400 mg, 800 mg dan 1200 mg.

    Bentuk sediaan:

    Ampul.

    Tablet salut selaput (400 mg).

    Kaplet salut selaput (800 dan 1200 mg).

    Farmakologi:

    Mekanisme kerja piracetam belum diketahui dengan pasti. Para peneliti memperkirakan kerja piracetam melindungi pasien terhadap hipoksia. Beberapa penelitian penelitian memperlihatkan bahwa piracetam melindungi otak melalui efek neuronal dan hemodinamik.

    Indikasi:

    Sediaan injeksi : Pengobatan infark serebral.

    Sediaan oral : Gejala involusi yang berhubungan dengan usia lanjut, alkoholisme kronik dan adiksi; dan gejala pasca trauma.

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    Dosis:

    Piracetam injeksi

    • Dosis yang dianjurkan : 1 g 3 x sehari, IV.

    Piracetam oral

    • Simtom Psikis – Organik yang berhubungan dengan usia lanjut :

    Dosis awal per hari : 2,4 g ( 6 tablet 400 mg atau 3 kaplet 800 mg atau 2 kaplet 1200 mg) terbagi dalam 2 – 3 waktu selama 6 minggu, diikuti dengan 1,2 g / hari sebagai dosisperawatan.

    • Simtom Pasca – Trauma : Dosis rata-rata : dosis awal : 2 tablet 400 mg atau 1 kaplet 800 mg, 3 kali sehari. Jika efek yang diharapkan telah tercapai, kurangi dosis secara bertahap menjadi 1 tablet 400 mg atau ½ kaplet 800 mg.

    Kontraindikasi:

    Penderita dengan insufisiensi ginjal yang berat (bersihan kreatinin < 20 mL /menit).

    Penderita yang hipersensitif terhadap piracetam atau derivat pirolidon lainnya.

    Penderita dengan perdarahan serebral.

    Peringatan dan Perhatian:

    Oleh karena piracetam seluruhnya dieliminasi melalui ginjal, dianjurkan melakukan pengecekan fungsi ginjal.

    Oleh karena efek piracetam pada agregasi platelet, peringatan diberikan pada penderita dengan ganggguan hemostasis, operasi besar atau pendarahan berat.

    Efek Samping:

    Nervousness, irritabilitas, insomnia, anxietas, tremor, agitasi, fatigue dan somnolence. Gangguan gastro-intestinal (nausea, vomiting, diare, gastralgia, sakit kepala, dan vertigo) pernah dilaporkan.

     

     

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    PIRACETAM OGB HJ

     

    Composition:

    Each mL injection solution contains piracetam 200 mg Each film coated tablet contains piracetam 400 mg Each film coated caplet contains piracetam 800 mg and 1200 mg

    Presentation:

    PIRACETAM injection 200 mg/mL: Box of 10 ampoules @ 5 mL Box of 4 ampoules @ 15 mL PIRACETAM film coated tablet 400 mg: Box of 5 strips x 10 tablets Box of 10 strips x 10 tablets PIRACETAM film coated caplet 800 mg: Box of 5 strips x 10 caplets Box of 10 strips x 10 caplets PIRACETAM film coated caplet 1200 mg: Box of 3 strips x 10 caplets

    Pharmacology:

    Piracetam is a nootropic agent.

    Indications:

    Injection: Treatment of cerebral infarction. Oral: Treatment of symptoms of involution related to old age, chronic alcoholism and addiction; and posttraumatic symptoms.

    Contraindications:

    - Patients with severe renal insufficiency (creatinine clearance <20 mL/min). - Hypersensitivity to piracetam or other pyrrolidone derivatives, including components of the drug. - Patients with cerebral haemorrhage.

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    Dosage:

    Injection: Recommended dosage: 1 g 3 times daily, intravenously. Oral: - Psychiatric-organic symptoms related to old age: The initial dose per day: 2.4 g (6 tablets 400 mg or 3 caplets 800 mg or 2 caplets 1200 mg) is divided into 2-3 times for 6 weeks, followed by 1.2 g/day as the treatment dose. - Post-traumatic symptoms: Average dose: initial dose of 2 tablets 400 mg or 1 caplet 800 mg, 3 times a day. If the expected effect is reached, reduce the dose gradually to 1 tablet 400 mg or ½ caplet 800 mg. Duration of treatment: In some acute cases, the effects of piracetam are immediately apparent, while in other cases, symptoms subside usually after the third week of administration. In order for piracetam to be more effective, continuous treatment is highly recommended.

    Warning and Precautions:

    - Because all piracetam is eliminated through the kidneys, a warning must be given to patients with kidney function disorders, therefore it is recommended to check kidney function and elderly patients. - Because of the effect of piracetam on platelet aggregation, caution is given to patients with impaired hemostasis, major surgery or heavy bleeding. - Avoid sudden discontinuation of the drug, because it can induce myoclonus or general seizures in people with myoclonus. - Doctors must consider the benefits compared to the risks if given to first quarter pregnant women and nursing mothers.

    Adverse events:

    Nervousness, irritability, insomnia, anxietas, tremor, agitation, fatigue, somnolence, gastrointestinal disturbance, dry mouth, increase in libido, body weight gain, skin hypersensitivity.

    Drugs Interaction:

    Case of confusion, irritability, and sleep disturbance has been reported, on administration together with thyroid extract (T3 + T4).

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