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MEFENAMIC ACID

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    Komposisi:

    Asam mefenamat 500 mg

    Bentuk sediaan:

    Kaplet

    Farmakologi:

    Mefenamic acid merupakan kelompok anti-inflamasi non-steroid (AINS), bekerja dengan cara menghambat sintesis prostaglandin dalam jaringan tubuh dengan menghambat enzim siklooksigenase, sehingga mempunyai efek analgesik, anti-inflamasi, dan anti-piretik.

    Indikasi:

    Meredakan nyeri ringan sampai sedang sehubungan dengan sakit kepala, sakit gigi, dismenore primer. Selain itu, digunakan pula pada keadaan yang termasuk: nyeri akibat trauma, nyeri otot, dan nyeri sesudah operasi.

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    Dosis dan Cara Pemberian:

    Dewasa dan anak-anak >14 tahun:
    Dosis awal: 500 mg, kemudian dianjurkan 250 mg tiap 6 jam sesuai dengan kebutuhan.

    Kontraindikasi:

    • Pasien yang hipersensitif terhadap mefenamic acid.

    • Penderita yang mengalami bronkospasme dengan aspirin, rinitis alergi, dan urtikaria.

    • Penderita dengan tukak lambung dan usus.

    • Penderita dengan gangguan ginjal yang berat.

    Peringatan dan Perhatian:

    • Sebaiknya diminum sesudah makan.

    • Hati-hati jika digunakan pada wanita hamil dan menyusui.

    • Keamanan pada anak-anak di bawah 14 tahun belum diketahui dengan pasti.

    • Kejadian trombotik kardiovaskular Untuk mengurangi risiko efek samping trombotik kardiovaskuler serius, infark miokard, dan stroke yang dapat berakibat fatal, AINS harus diberikan dengan dosis efektif terendah dan lama pengobatan sesingkat mungkin.

    • Hipertensi AINS, termasuk mefenamic acid, dapat menyebabkan munculnya hipertensi baru atau memperberat hipertensi yang sudah ada yang dapat berakibat pada peningkatan efek samping KV. AINS, termasuk mefenamic acid, harus digunakan dengan hati-hati pada pasien hipertensi. Tekanan darah harus dimonitor sejak awal dan selama terapi dengan AINS.

    • Gagal jantung kongestif dan edema Retensi cairan dan edema telah terlihat pada beberapa pasien yang menggunakan AINS. Mefenamic acid harus digunakan dengan hati-hati pada pasien dengan retensi cairan atau gagal jantung

    • Saluran cerna AINS, termasuk mefenamic acid, dapat menyebabkan efek samping saluran cerna serius termasuk inflamasi, perdarahan, ulserasi, dan perforasi lambung dan usus yang dapat berakibat fatal. Efek samping serius ini dapat terjadi kapanpun, dengan atau tanpa gejala peringatan.

    Efek Samping:

    • Sistem pencernaan: mual, muntah, diare, dan rasa sakit pada abdominal.

    • Sistem hematopoietik: leukopenia, eosinofilia, trombositopenia, dan agranulositopenia

    • Sistem saraf: rasa mengantuk, pusing, pengihatan kabur, dan insomnia.

     

     

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    MEFENAMIC ACID OGB HJ

     

    Composition:

    500 mg Mefenamic acid

    Presentation:

    Caplet, box: 10 strips x 10 caplets.

    Pharmacology:

    Mefenamic acid is a non-steroidal anti-inflammatory group (NSAID), works by inhibiting prostaglandin synthesis in body tissues by inhibiting the cyclooxygenase enzyme, so that it has an analgesic, anti-inflammatory, and anti-pyretic effect.

    Indications:

    Relieves mild to moderate pain associated with headaches, toothache, primary dysmenorrhea. In addition, it is also used in conditions that include: pain due to trauma, muscle pain, and pain after surgery.

    Contraindications:

    • Patients who are hypersensitive to mefenamic acid. • Patients who experience bronchospasm with aspirin, allergic rhinitis, and urticaria. • Patients with gastric and intestinal ulcers. • Patients with severe kidney impairment.

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    Dosage:

    Adults and children> 14 years old: Initial dose: 500 mg, then it is recommende to give 250 mg every 6 hours based on the condition.

    Warning and Precautions:

    • You should take it after meals. • Be careful if used in pregnant and lactating women. • Safety for children under 14 years is not fully known. • Cardiovascular thrombotic events: To reduce the risk of serious cardiovascular thrombotic side effects, myocardial infarction, and strokes that can be fatal, NSAIDs should be given with the lowest effective dose and the shortest possible treatment duration. • Hypertension of NSAIDs, including mefenamic acid, can cause the appearance of new hypertension or aggravate existing hypertension which can result in increased side effects of cardiovascular. NSAIDs, including mefenamic acid, must be used with caution in hypertensive patients. Blood pressure must be monitored from the start and during therapy with NSAIDs. • Congestive heart failure and edema: Fluid retention and edema have been seen in some patients using NSAIDs. Mefenamic acid must be used with caution in patients with fluid retention or heart failure. • Gastrointestinal tract: NSAIDs including mefenamic acid, can cause serious gastrointestinal side effects including inflammation, bleeding, ulceration, and perforation of the stomach and intestines which can be fatal. These serious side effects can occur at any time, with or without warning symptoms.

    Adverse events:

    • Digestive system: nausea, vomiting, diarrhea, and abdominal pain. • Hematopoietic system: leucopenia, eosinophilia, thrombocytopenia, and agranulocytopenia. • Nervous system: drowsiness, dizziness, blurred vision, and insomnia.

    Drugs Interaction:

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