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LEUCOVORIN

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    Komposisi:

    Leucovorin 50 mg/5 mL.

    Bentuk sediaan:

    Cairan injeksi dalam vial.

    Farmakologi:

    Mekanisme kerja (untuk pasien kanker): meningkatkan efektivitas 5-fluorouracil. Tmax 1,5-2 jam, 80-90% diekskresikan melalui ginjal.

    Indikasi:

    Menetralkan toksisitas antagonis folic acid (methotrexate), anemia megaloblastik.

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    Dosis:

    Kombinasi 5-fluorouracil: sesuai regimen. Menetralkan efek toksik methotrexate: 10 mg/m2 setiap 6 jam, kemudian disesuaikan.

    Kontraindikasi:

    Anemia pernisiosa/akibat defisiensi vitamin B12.

    Peringatan dan Perhatian:

    Perlu pemantauan kadar methotrexate serum, wanita hamil/menyusui.

    Efek Samping:

    Reaksi alergi (jarang), demam.

     

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    LEUCOVORIN

     

    Composition:

    Leucovorin Calcium..

    Presentation:

    Solution for injection in vial of 50 mg/5 mL.

    Pharmacology:

    Mechanism of action (for cancer patients): increasing the efficacy of 5-fluorouracil. Tmax 1.5-2 hours, 80-90% of the dose is eliminated through the kidney.

    Indications:

    Neutralising the immediate toxic effects of folic acid antagonist (methotrexate), megaloblastic anemia.

    Contraindications:

    Pernicious anemia or other megaloblastic anemia where vitamin B12 is deficient.

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    Dosage:

    In combination with fluorouracil: dosage depends on the regimen. Neutralising the toxic effects of methotrexate: 10 mg/m2 every 6 hours, the subsequent dose is modified.

    Warning and Precautions:

    Methotrexate serum concentration should be monitored, pregnancy & breastfeeding woman.

    Adverse events:

    Allergic reactions (occasionally), pyrexia.

    Drugs Interaction:

    Concomitant administration with fluorouracil may increase the toxicity of fluorouracil.

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