FLUOROURACIL

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    Komposisi:

    - 5-Fluorouracil 500 mg/10 mL.

    - 5-Fluorouracil 250 mg/5 mL

    Bentuk sediaan:

    Cairan injeksi dalam ampul dan vial 500 mg/10 mL.

    Farmakologi:

    Mekanisme kerja: menghambat pembentukan thymine yang diperlukan untuk sintesis DNA. Metabolisme di hati menjadi bentuk tidak aktif, ekskresi terutama melalui ginjal.

    Indikasi:

    Kanker kolon, kanker rektum, kanker payudara, kanker lambung, kanker pankreas.

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    Dosis:

    Bervariasi (maksimum 800 mg/hari).

    Kontraindikasi:

    Status nutrisi buruk, mielosupresi, hipersensitif.

    Peringatan dan Perhatian:

    Hati-hati pada pasien dengan radioterapi dosis tinggi, pernah mendapat agen pengalkil, metastatik ke sumsum tulang, wanita hamil/menyusui.

    Efek Samping:

    Stomatitis, diare, mual muntah, leukopenia, alopesia, dermatitis.

     

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    FLUOROURACIL

     

    Composition:

    5-Fluorouracil.

    Presentation:

    Solution for injection in vial of 500 mg/10 mL.

    Pharmacology:

    Mechanism of action: blocking the formation of thymine used for DNA synthesis. It is metabolized in the liver to inactive metabolites, excreted primarily in urine.

    Indications:

    Colon cancer, rectal cancer, breast cancer, gastric cancer, pancreatic cancer.

    Contraindications:

    Poor nutritional state, depressed bone marrow function, potentially serious infection, known hypersensitivity to this drug.

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    Dosage:

    The dose depends on the regimen used (maximum daily dose is 800 mg/day).

    Warning and Precautions:

    Use with caution in patients with history of high risk irradiation, previous use of alkylating agent, who have widespread involvement of bone marrow by metastatic tumours. Pregnancy and lactation.

    Adverse events:

    Stomatitis, diarhhea, nausea vomiting, leukopenia, alopecia, dermatitis.

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