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EPIRUBICIN

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    Komposisi:

    - Epirubicin 10 mg/5 mL.

    - Epirubicin 50 mg/25 mL.

    Bentuk sediaan:

    Cairan injeksi dalam vial.

    Farmakologi:

    Mekanisme kerja: menghambat enzim topoisomerase II sehingga menghambat proses pembelahan sel dan pembentukan DNA. Eliminasi lambat, ekskresi terutama melalui empedu.

    Indikasi:

    Kanker payudara, limfoma maligna, sarkoma jaringan lunak, kanker lambung.

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    Dosis:

    60-90 mg/m2.

    Kontraindikasi:

    Mielosupresi, penyakit jantung, telah mendapat dosis kumulatif maksimum anthracycline, hipersensitif, kehamilan.

    Peringatan dan Perhatian:

    · Perlu pemantauan hematologi, fungsi hati, dan jantung

    · Dapat menyebabkan perubahan warna urin.

    Efek Samping:

    Mielosupresi, gangguan fungsi jantung, alopesia, mual-muntah, stomatitis, hiperpireksia.

     

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    EPIRUBICIN

     

    Composition:

    Epirubicin

    Presentation:

    Solution for injection in vials 10 mg/5 mL and 50 mg/25 mL.

    Pharmacology:

    Mechanism of action: Mechanism of action: freezing the enzyme DNA topoisomerase II resulting in inhibition of cell division and DNA synthesis. Slow elimination, predominantly excreted in bile.

    Indications:

    Breast cancer, malignant lymphoma, soft tissue sarcoma, gastric cancer.

    Contraindications:

    Myelosuppression, pre-existing heart disease, previous treatment with complete cumulative doses of anthracycline, hypersensitivity reaction, pregnancy.

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    Dosage:

    60-90 mg/m2.

    Warning and Precautions:

    - Evaluation of hematologic, liver and heart functions. - Causing red colouration to urine.

    Adverse events:

    Myelosuppression, cardiotoxicity, alopecia, nausea-vomiting, stomatitis, hyperpyrexia.

    Drugs Interaction:

    Heparin

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