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CIPROFLOXACIN OGB HJ

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    Komposisi:

    Ciprofloxacin HCl 250 mg, 500 mg, dan 200 mg/100 mL.

    Bentuk sediaan:

    - Tablet salut selaput.

    - Infus.

    Farmakologi:

    Menghambat replikasi DNA bakteri dengan menghambat enzim DNA Gyrase dan Toposiomerase IV.

    Indikasi:

    - Infeksi saluran kemih termasuk prostatitis.

    - Uretritis dan servisitis gonnorhea.

    - Infeksi tulang dan sendi.

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    Dosis:

    - Tablet: 2 x 250 - 750 mg / hari

    - Infus:

    - Infeksi ginjal tanpa komplikasi dan infeksi saluran kemih bagian atas dan bawah : 2 x 100 mg sehari.

    - Infeksi lain : 2 x 200 mg sehari.

    - Gonnorhea akut dan sistitis akut tanpa komplikasi pada wanita: infus tunggal 100 mg.

    Kontraindikasi:

    - Hipersensitif terhadap quinolone.

    - Anak dalam masa pertumbuhan.

    - Ibu hamil dan menyusui.

    Peringatan dan Perhatian:

    - Keamanan dan efektivitas pada wanita hamil dan menyusui belum dapat ditentukan (kategori C)

    - Ciprofloxacin harus ditelan dengan air secukupnya untuk mencegah kristaluria.

    - Hati-hati pemberian pada penderita dengan gangguan ginjal.

    Efek Samping:

    - Saluran cerna : Mual, muntah, diare, gangguan pencernaan, dispepsia, nyeri abdomen, kembung, anoreksia, disfagia.

    - Sistem saraf: Pusing, sakit kepala, rasa letih, insomnia, agitasi, tremor.

     

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    CIPROFLOXACIN OGB HJ

     

    Composition:

    Ciprofloxacin hydrochloride.

    Presentation:

    - Enteric coated tablet 500 mg: box contains 10 strips x 10 tablets. - Infusion 200 mg/100 mL: 1 vial contains 100 mL solution.

    Pharmacology:

    Inhibits bacterial DNA replication by inhibiting of the enzymes DNA gyrase and topoisomerase IV.

    Indications:

    - Urinary tract infections including prostatitis. - Uretritis and cervicitis gonorrhea. - Bone and joint infections.

    Contraindications:

    - Hypersensitivity to quinolone - Children in their infancy - Pregnancy and lactation

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    Dosage:

    - Tablets: 2 x 250 - 750 mg / day - Infusion: - Uncomplicated kidney infection and upper and lower urinary tract infections: 2 x 100 mg daily. - Other infections: 2 x 200 mg daily. - Acute gonnorhea and uncomplicated acute cystitis in women: single infusion of 100 mg.

    Warning and Precautions:

    - The safety and effectiveness in pregnant and lactating women can not be determined (category C). - Ciprofloxacin must be swallowed with enough water to prevent crystalluria. - Be careful about giving to patients with kidney disorders.

    Adverse events:

    - Effects on the gastrointestinal tract: nausea, vomiting, diarrhea, indigestion, dyspepsia, abdominal pain, bloating, anorexia, dysphagia. - Effects on the nervous system: dizziness, headache, fatigue, insomnia, agitation, tremor.

    Drugs Interaction:

    - Medications that affect gastric acidity (antacids) containing aluminum or magnesium hydroxide will reduce ciprofloxacin absorption. Therefore ciprofloxacin must be swallowed 1-2 hours before or at least 4 hours after taking antacids. This limitation does not apply to antacids which do not contain aluminum or magnesium hydroxide. - Giving concomitantly with theophylline can increase theophylline levels in plasma so that it can cause theophylline side effects. If this combination can not be avoided, plasma theophylline levels must be monitored and the theophylline dose should be reduced. If theophylline levels can not be monitored, ciprofloxacin administration should be avoided. - A temporary increase in serum creatinine levels was seen in ciprofloxacin with cyclosporine. In this case, serum creatinine levels must be monitored frequently (twice a week). - It must be considered the possibility of interaction with Girabloc and Probenecid. - Giving concomitantly with oral anti-coagulants can prolong the bleeding time. - Giving concomitantly with metoclopramide accelerates Girabloc absorption.

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