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CEFTRIAXONE OGB HJ

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    Komposisi:

    Ceftriaxone .

    Bentuk sediaan:

    Vial 1 g : Dus isi 2 vial

    Farmakologi:

    Menghambat sintesis dinding sel bakteri sehingga terjadi kebocoran sel bakteri dan bakteri lisis.

    Indikasi:

    infeksi saluran napas, infeksi THT, infeksi saluran kemih, sepsis, meningitis, infeksi tulang, sendi dan jaringan lunak, infeksi intra abdominal dll.

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    Dosis:

    - Dewasa dan anak > 12 tahun : 1 - 2 gram satu kali sehari. dosis dapat dinaikkan sampai 4 gram satu kali sehari.

    - Ceftriaxone dapat diberikan secara injeksi I.V. dan I.M.

    - Anak: 30 - 50 mg/kgBB/hari.

    Kontraindikasi:

    - Hipersensitif terhadap antibiotik cephalosporin.

    - Neonatus.

    Peringatan dan Perhatian:

    - Pregnancy category B.

    - Pada pasien dengan gangguan fungsi ginjal dan hati yang berat, kadar plasma obat perlu dipantau.

    Efek Samping:

    - Gastrointestinal : faeces encer / diare, mual, muntah, stomatitis dan glositis.

    - Kulit : pruritus, urtikaria, dermatitis alergi, udema, eksantem, eritema multiforma.

    Interaksi Obat:

    Kombinasi dengan aminoglycoside dapat menghasilkan efek aditif atau sinergis, khususnya pada infeksi berat yang disebabkan oleh P. aeruginosa dan S. faecalis.

     

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    CEFTRIAXONE OGB HJ

     

    Composition:

    Ceftriaxone

    Presentation:

    Vial 1 g: Box of 2 vials

    Pharmacology:

    Inhibits bacterial cell wall synthesis resulting in leakage of bacterial and lysis bacteria cells.

    Indications:

    Respiratory infections, ENT infections, urinary tract infections, sepsis, meningitis, bone infections, joints and soft tissues, intra-abdominal infections etc.

    Contraindications:

    - Hypersensitivity to cephalosporin antibiotics. - Neonate.

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    Dosage:

    - Adults and children> 12 years: 1-2 grams once a day. the dosage can be increased to 4 grams once a day. - Ceftriaxone can be given by injection I.V. and I.M. - Children: 30-50 mg / kg / day.

    Warning and Precautions:

    - Pregnancy category B. - In patients with severe kidney and liver dysfunction, plasma drug levels need to be monitored.

    Adverse events:

    - Gastrointestinal: dilute faeces / diarrhea, nausea, vomiting, stomatitis and glossitis. - Skin: pruritus, urticaria, allergic dermatitis, udema, exanthem, erythema multiforme.

    Drugs Interaction:

    Combinations with aminoglycoside can produce additive or synergistic effects, especially in severe infections caused by P. aeruginosa and S. faecalis.

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