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IFEN

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    Komposisi:

    Ibuprofen 200 dan 400 mg

    Bentuk sediaan:

    Tablet

    Farmakologi:

    Bekerja sebagai antiinflamasi, analgesik, dan antipiretik melalui penghambatan prostaglandin dengan menghambat enzim cyclooxygenase.

    Indikasi:

    - IFEN diindikasikan untuk pengobatan simtomatik artritis reumatoid dan osteoartritis, pada fase akut dan untuk pengobatan jangka panjang.

    - IFEN juga diindikasikan untuk pengobatan rasa nyeri yang ringan sampai sedang.

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    Dosis:

    Dewasa :

    - artritis reumatoid dan osteoartritis: Sehari 3 - 4 x 1 tablet 200 mg atau 400 mg, disesuaikan dengan kebutuhan masing-masing penderita.

    - Nyeri ringan sampai sedang: 200 - 400 mg tiap 4 - 6 jam sesuai kebutuhan.

    Kontraindikasi:

    - Ulkus peptikum

    - Ibu hamil trimester III

    - Bronkospasme, alergi rinitis dan urtikaria karena asetosal

    - Hipersensitif terhadap ibuprofen

    Peringatan dan Perhatian:

    - Hindarkan penggunaan pada kehamilan trimester 3 karena dapat menyebabkan penutupan dini duktus arteriosus

    - Pemberian bersama dengan NSAID lain

    Efek Samping:

    Gangguan saluran cerna, gangguan pembekuan darah, gangguan kardiovaskuler, reaksi hipersensitif, gangguan fungsi ginjal.

     

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    IFEN

     

    Composition:

    Ibuprofen 200 mg and 400 mg.

    Presentation:

    Tablet 200 mg : Box contains 10 strips x 10 tablets Tablet 400 mg : Box contains 10 strips x 10 tablets.

    Pharmacology:

    Works as an anti-inflammatory, analgesic and antipyretic by inhibiting the activity of cyclooxygenase (COX) enzyme which leads to the formation of prostaglandins.

    Indications:

    - IFEN is indicated for symptomatic treatment of rheumatoid arthritis and osteoarthritis, in the acute phase and for long-term treatment. - IFEN is also indicated for the treatment of mild to moderate pain.

    Contraindications:

    - Peptic ulcer - Third trimester of pregnancy - Bronchospasm, allergic to rhinitis and urticaria due to acetosal - Hypersensitivity to ibuprofen.

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    Dosage:

    Adult: - Rheumatoid arthritis and osteoarthritis: 3-4 x 1 tablet 200 mg or 400 mg/day, adjusted to the needs of each patient. - Mild to moderate pain: 200 - 400 mg every 4 - 6 hours as needed.

    Warning and Precautions:

    - Ifen should be avoided in the third trimester of pregnancy because it may cause premature closure of the ductus arteriosus. - Concomitant use with other NSAIDs.

    Adverse events:

    Gastrointestinal disorders, blood clotting disorders, cardiovascular disorders, hypersensitivity reactions, impaired kidney function.

    Drugs Interaction:

    - Use with acetylsalicylic acid or other NSAIDs may result in possible additive adverse side effects. - Use with acetaminophen, may increase the risk of adverse renal effect. - Use with anticoagulants may increase the risk of GI adverse events (e.g., bleeding). - Use with hypoglycemic agents (oral agents and insulin) may increase the risk of hypoglycaemia. - Use with antihypertensives may interfere with circulatory control. - Use with diuretics may reduce the diuretic effect. - Use with methotrexate may increase the risk of methotrexate toxicity. - Use with lithium may increase the risk of lithium toxicity.

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