KALMICETIN

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    Komposisi:

    Chloramphenicol

    Bentuk sediaan:

    - Kapsul 250 mg : 
       Dus berisi 10 blister x 10 kapsul 
       Dus berisi 30 blister x 10 kapsul 
    - Sirup 125 mg / 5 mL: Botol berisi 60 mL suspensi

    Farmakologi:

    Menghambat sintesis protein bakteri reversibel.

    Indikasi:

    - Demam tifoid & paratifoid, 
    - Untuk infeksi-infeksi berat yang disebabkan oleh:
    Salmonella sp., H. influenzae (terutama infeksi meningeal), Rickettsia, Limphogranuloma, Psittachosis, Gram-negatif yang menyebabkan bakteremia meningitis.

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    Dosis:

    - Dewasa, anak, dan bayi berumur >2 minggu: 50 mg/kg BB sehari dibagi menjadi 3-4 dosis.
    - ?Bayi berumur <2 minggu:  25 mg/kg BB sehari dibagi menjadi 4 dosis.

    Kontraindikasi:

    - Hipersensitif

    - Gangguan hati atau ginjal derajat berat.

    Peringatan dan Perhatian:

    Hati-hati risiko anemia aplastik

    Efek Samping:

    Diskrasia darah, depresi sumsum tulang, gangguan saluran cerna misal mual, muntah, diare, sindrom Gray pada bayi prematur dan baru lahir.

    Interaksi Obat:

    Kloramfenikol menghambat biotransformasi senyawa lain yang dimetabolisme oleh enzim mikrosoma hati seperti dikumarol, fenitoin, tolbutamida dan turunan sulfonylurea lainnya.

     

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    KALMICETIN

     

    Composition:

    Chloramphenicol

    Presentation:

    - Capsules of 250 mg: Box of 10 blister x 10 capsules Box of 30 blister x 10 capsules - Syrup 125 mg / 5 mL: Bottle contains 60 mL of suspension

    Pharmacology:

    Inhibits reversible bacterial protein synthesis.

    Indications:

    - Typhoid & paratyphoid fever - For severe infections caused by: Salmonella sp., H. influenzae (especially meningeal infection), Rickettsia, Limphogranuloma, Psittachosis, Gram-negative causes of bacterial meningitis.

    Contraindications:

    - Hypersensitivity - Severe degrees of liver or kidney disorders

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    Dosage:

    - Adults, children and infants> 2 weeks old: 50 mg / kg BW daily divided into 3-4 doses. - Babies <2 weeks old: 25 mg / kg BW daily divided into 4 doses.

    Warning and Precautions:

    Beware of the risk of aplastic anemia

    Adverse events:

    Blood dyscrasias, bone marrow depression, gastrointestinal disorders such as nausea, vomiting, diarrhea, Gray syndrome in premature babies and newborns.

    Drugs Interaction:

    Chloramphenicol inhibits the biotransformation of other compounds metabolized by liver microsome enzymes such as dikumarol, phenytoin, tolbutamide and other sulfonylurea derivatives.

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