KALMETHASONE

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    Komposisi:

    Tiap tablet mengandung Dexamethasone 0,5 mg

    Bentuk sediaan:

    Tablet

    Farmakologi:

    Dexamethasone adalah glukokortikoid mempunyai efek sedikit menahan sodium. Absorbsi peroral 80-90%. Waktu paruh plasma: 3-4 jam. Waktu paruh biologis: 36-54 jam. Waktu mencapai kadar puncak: 1-2 jam. Metabolisme terutama di hati. Ekskresi melalui urine.

    Indikasi:

    Pengobatan radang dan alergi dan penyakit responsif glukokortikoid lain.

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    Dosis:

    Diberikan secara individual dengan dosis inisial 0,75 sampai 9 mg per hari.

    Kontraindikasi:

    Ocular herpes simplex, infeksi jamur

    Peringatan dan Perhatian:

    - Pada pemakaian jangka panjang dapat menimbulkan gejala putus obat meliputi demam, mialgia, artralgia, dan malaise.

    - Hati-hati penggunaan dengan aspirin

    Efek Samping:

    Retensi garam dan air, kelemahan otot, ulkus peptikum.

     

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    KALMETHASONE

     

    Composition:

    Each tablet contains dexamethasone 0.5 mg

    Presentation:

    Tablet.

    Pharmacology:

    Dexamethasone is glucocorticoid which has a slight effect on sodium. Oral absorption dexamethasone is 80-90%. Plasma half-life: 3-4 hours. Biological half-life: 36-54 hours. Time reaches peak levels: 1-2 hours. Metabolism, especially in the liver with urinary excretion.

    Indications:

    Treatment of inflammation and allergies and other glucocorticoid responsive diseases.

    Contraindications:

    Ocular herpes simplex, fungal infection

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    Dosage:

    Dosage is individual, with initial doses of 0.75 to 9 mg per day.

    Warning and Precautions:

    - Long-term use can cause withdrawal symptoms, including fever, myalgia, arthralgia, and malaise. - Caution should be made when dexamethasone is being given along with aspirin

    Adverse events:

    Salt and water retention, muscle weakness, peptic ulcer.

    Drugs Interaction:

    -

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