CISPLATIN

CISPLATIN

  •  

    find pharmacy

    Komposisi:

    - Cisplatin 10 mg/10 mL.

    - Cisplatin 50 mg/50 mL.

    Bentuk sediaan:

    Cairan injeksi dalam vial.

    Farmakologi:

    Mekanisme kerja: berikatan dengan DNA sehingga menyebabkan hambatan replikasi dan transkripsi.

    Ekskresi terutama melalui ginjal (27-43%).

    Indikasi:

    Kanker testis, kanker ovarium, kanker kandung kemih.

    shopping online

    Dosis:

    50-120 mg/m2.

    Kontraindikasi:

    Gangguan fungsi ginjal, mielosupresi, gangguan pendengaran, hipersensitif, kehamilan & laktasi.

    Peringatan dan Perhatian:

    - Perlu prahidrasi dan pascahidrasi, pemantauan kadar elektrolit, hematologi, fungsi ginjal, saraf, pendengaran, hati.

    - Umumnya perlu premedikasi anti-mual muntah.

    Efek Samping:

    Nefrotoksik, ototoksik, mielosupresi, mual muntah, neurotoksik, reaksi alergi, gangguan elektrolit serum, hiperurisemia.

     

    find pharmacy

    CISPLATIN

     

    Composition:

    Cisplatin

    Presentation:

    Solution for injection in vials of 10 mg/10 mL and 50 mg/50 mL.

    Pharmacology:

    Mechanism of action: binding to DNA that leads to inhibition of replication and transcription. Cisplatin is excreted primarily in the urine (27-43%).

    Indications:

    Testicular cancer, ovarian cancer, bladder cancer.

    Contraindications:

    Renal impairment, myelosuppressed patients, hearing impairment, hypersensitivity to cisplatin or other platinum containing compounds, pregnancy & breastfeeding woman.

    shopping online

    Dosage:

    50-120 mg/m2 every 3-4 weeks or 50 mg/m2 on days 1 & 8 every 3-4 weeks or 15-20 mg/m2 on days 1-5 every 3-4 weeks.

    Warning and Precautions:

    - Prehydration and posthydration therapy, individual counter measures: electrolyte test, hematological test, renal function, neurologic function, hearing function test, liver function. - Prophylactic use of anti-emetic.

    Adverse events:

    Nephrotoxicity, ototoxicity, myelosuppression, nausea vomiting, neurotoxicity, allergic reactions, serum electrolyte disturbances, hyperuricemia.

    Drugs Interaction:

    - Nephrotoxic and ototoxic substances - Penicillamine - Bleomycin dan methotrexate - Pyridoxine dan hexamethylamine - Docetaxel - Live vaccine

Please login or register to post comments.