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NEURALGIN RHEMA

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    Komposisi:

    - Diclofenac sodium 50 mg

    - Thiamine mononitrate 50 mg

    - Pyridoxine HCI 50 mg

    - Cyanocobalamin 1 mg

    Bentuk sediaan:

    Kaplet salut selaput

    Farmakologi:

    - Diclofenac bekerja sebagai antiinflamasi, analgesik melalui penghambatan prostaglandin dengan menghambat enzim cyclooxygenase.

    - Vitamin B untuk membantu mengatasi nyeri terkait gangguan saraf seperti neuritis atau neuralgia

    Indikasi:

    - Pengobatan pada dismenore primer

    - Meredakan nyeri ringan hingga sedang

    - Meredakan gejala dan tanda osteoarthritis

    - Meredakan gejala dan tanda rheumatoid arthritis

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    Dosis:

    - Dosis maksimal 100 mg per hari (dosis awal maksimal 150 mg sehari pada hari pertama) dalam dosis terbagi dan dengan durasi sesingkat mungkin.

    - Apabila berdasarkan penilaian dokter diperlukan dosis yang lebih tinggi, harus ada pertimbangan manfaat-risiko dengan baik.

    Kontraindikasi:

    - Hipersensitif terhadap zat aktif dan tukak lambung.

    - Juga dikontraindikasikan pada pasien dengan riwayat tercetusnya serangan asma, urtikaria atau rinitis akut akibat obat-obat anti-inflamasi non-steroid lainnya.

    - Penyakit jantung iskemik.

    - Penyakit arteri perifer.

    - Penyakit serebrovaskuler.

    - Gagal jantung kongestif (NYHA (New York Heart Association) kelas II-IV).

    Peringatan dan Perhatian:

    - Hindarkan penggunaan pada kehamilan trimester 3 karena dapat menyebabkan penutupan dini duktus arteriosus

    - Pemberian bersama dengan NSAID lain

    Efek Samping:

    Gangguan saluran cerna, gangguan pembekuan darah, gangguan kardiovaskuler, reaksi hipersensitif, gangguan fungsi ginjal.

     

     

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    NEURALGIN RHEMA

     

    Composition:

    - Diclofenac sodium 50 mg - Thiamine mononitrate 50 mg - Pyridoxine HCI 50 mg - Cyanocobalamin 1 mg

    Presentation:

    Film-coated caplet in a box containing 10 blisters @ 10 film-coated caplets.

    Pharmacology:

    - Diclofenac is anti-inflammatory drug and analgesic. Its mechanism of action is blocking the effect of cyclooxygenase enzyme needed to synthesize prostaglandin. - Vitamin B helps to reduce nerve dysfunction such as neuritis and neuralgia.

    Indications:

    - Treatment of primary dysmenorrhea - For relief of mild to moderate pain - For relief of the signs and symptoms of osteoarthritis - For relief of the signs and symptoms of rheumatoid arthritis

    Contraindications:

    - Known hypersensitivity to diclofenac. - Patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. - Treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG).

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    Dosage:

    - Maximum dose of 100 mg daily (initial maximum dose is 150 mg daily on the first day) in divided doses and the shortest duration. - If higher dose is needed based on clinician's judgement, the possible risks should be weighed against the expected benefits.

    Warning and Precautions:

    - Avoid using this drug in third trimester of pregnancy because it may cause premature closed of arteriosus duct. - Avoid the concomitant use with other NSAIDs.

    Adverse events:

    GI disorders, blood coagulation disorders, cardiovascular disorders, hypersensitivity reactions, renal function impairment.

    Drugs Interaction:

    Aspirin. Diclofenac may increase plasma concentration of digoxin, methotrexate, cyclosporine and lithium. Diclofenac may decrease diuretics activity. NSAID may diminish the anti-hypertensive effect of ACE inhibitors.

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