SUPRANE

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    Komposisi:

    Desflurane 100%

    Bentuk sediaan:

    Cairan inhalasi dalam botol kaca 240 mL

    Farmakologi:

    Merupakan anestetik inhalasi berhalogen dengan onset dan pulih sadar yang sangat cepat, bau agak tajam, MAC sekitar 6%, metabolisme di hati minimal (0,017%), dan stabil terhadap CO2 absorbent

    Indikasi:

    - Induksi dan pemeliharaan anestesi umum pada dewasa.

    - Pemeliharaan anaestesi umum pada anak.

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    Dosis:

    Induksi anestesi:

    - Mulai dosis 3%, ditingkatkan bertahap 0,5-1% setiap 2-3 hembusan napas

    Pemeliharaan anestesi:

    Dewasa:

    - 2-6% SUPRANE + N2O/O2

    - 2,5-8,5% SUPRANE + O2 murni

    Anak-anak:

    - 5,2-10% SUPRANE dgn/tanpa N2O

    Gangguan fungsi hati dan ginjal:

    - 1-4% SUPRANE dalam N2O/O2

    Kontraindikasi:

    Hipersensitif terhadap anestetik berhalogen, pasien yang diketahui atau mempunyai kerentanan genetik terhadap hipertermia maligna, pasien yang mempunyai gangguan fungsi hati, jaundice atau demam yang tidak dapat dijelaskan, leukositosis, atau eosinofilia yang terjadi setelah pemberian anestetik berhalogen sebelumnya.

    Peringatan dan Perhatian:

    - Diberikan dengan vaporizer khusus desflurane.

    - Tidak diindikasikan untuk induksi pada bayi dan anak.

    Efek Samping:

    Hipotensi, depresi napas, batuk, laringospasme dan apnu pada induksi, mual, muntah, hipertermia maligna.

     

     

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    SUPRANE

     

    Composition:

    Desflurane 100%.

    Presentation:

    Inhalation liquid in glass bottle 240 mL. Box contains 1 glass bottle 240 mL.

    Indications:

    Suprane is indicated as an inhalation agent for induction and maintenance of anaesthesia in adults and maintenance of anaesthesia in infants and children. Suprane is not recommended for induction of anaesthesia in paediatric patients.

    Contraindications:

    • Hypersensitive to halogenated anaesthetics.

    • Known or suspected genetic disposition toward malignant hyperthermia. • Patients with a history of malilgnant hyperthermia, or in whom liver dysfunction, jaundice or unexplained fever, leucocytosis, or eosinophilia has ocured after a previous halogenated anaesthetics administration.

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    Dosage:

    Induction of anaesthesia:

    • In adults, some premedicated with opioids, a frequent starting concentration was 3% Suprane, increased in 0,5-1,0% increments every 2 to 3 breaths. Inspired concentrations of 4-11% Suprane produce surgical anaesthesia in 2-4 minutes.

    Maintenance of anaesthesia:

    • Surgical levels of anaesthesia may be sustained with 2-6% concentration of Suprane when nitrous oxide is used concomitantly. Suprane at 2,5-8,5% may be required when administered using oxygen or oxygen enriched air.

    • In children, surgical laevels of anaesthesia may be maintained with concentration of 5,2-10% Suprane with or without the concomitant use of nitrous oxide.

    Renal and hepatic impairment:

    • Concentrations of 1-4% Suprane in nitrous oxide/oxygen have been used in patients with chronic renal or hepatic impairment and during renal transplantation surgery. .

    Warning and Precautions:

    • Suprane is not recommended for use as an inhalation induction agent in paediatric patients because of the frequent occurrence of cough, breath holding, apnoea, laryngospasm and increased secretions in children under 12 years. • Suprane should not be used as the sole agent for anesthetic induction in patients risk of coronary artery disease or in patients where increases in heart rate or blood pressure are undesirable. • Due to limited experience in neurosurgical patients, Suprane can not be recommended in this group. • Use of Suprane in hypovolemic, hypotensive and debilitated patients has not been extensively investigated. As with other potent inhaled anaesthetics, a lower concentration is recommended for use in these patients.

    Adverse events:

    As with all potent inhaled anaesthetics, Suprane may cause dose dependent hypotension. A dose-dependent repiratory depression is also observed. Most other adverse events are mild and transient. .

    Drugs Interaction:

    • No clinically significant adverse interactions with commonly used preanaesthetic drugs, or drugs used during anaesthesia (muscle relaxants, intravenous agents, and local anaesthetic agents) were reported in clinical trials. • Commonly used muscle relaxants are potentiated by Suprane. Lower doses of Suprane are required in patients receiving opioids, benzodiazepines or other sedatives.

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