TRANSMUCO

 

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Komposisi:

Ambroxol HCl 30 mg dan 15 mg/5 mL

Bentuk sediaan:

Tablet dan sirup

Farmakologi:

Menstimulasi sekresi sekret dari saluran napas

Indikasi:

Sebagai sekretolitik pada gangguan saluran nafas akut dan kronis khususnya pada eksaserbasi bronkitis kronis dan bronkitis asmatik dan asma bronkial.

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Dosis:

- Tablet:

Dewasa dan anak diatas 12 tahun : 1 tablet 2 - 3 kali sehari.

Anak-anak 6 - 12 tahun : ½ tablet 2 - 3 kali sehari.

- Sirup:

Anak 6-12 tahun: 5 mL, 2-3 kali sehari

Anak 2-6 tahun: 2,5 mL, 3 kali sehari

Anak < 2 tahun: 2,5 mL, 2 kali sehari

Kontraindikasi:

- Hipersensitif terhadap analgesik opioid

- Risiko ketergantungan opioid

Peringatan dan Perhatian:

- Pemakaian selama kehamilan dan menyusui masih memerlukan penelitian lebih lanjut.

- Ambroxol tidak boleh digunakan dalam jangka waktu yang lama tanpa konsultasi dokter

Efek Samping:

- Reaksi intoleran setelah pemberian Ambroxol yang pernah dilaporkan tetapi jarang.

- Efek samping yang ringan pada saluran-saluran cerna pernah dilaporkan pada beberapa pasien.

 

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TRANSMUCO

 

Composition:

Each tablet contains: Ambroxol hydrochloride 30 mg Each 5 mL syrup contains: Ambroxol hydrochloride 15 mg

Presentation:

TRANSMUCO tablet: Box of 3 strips x 10 tablets TRANSMUCO syrup: Box of 1 bottle 60 mL

Pharmacology:

Ambroxol has a secretolytic properties, stimulates secretion thick and sticky secret from the respiratory tract.

Indications:

As a secretolytic at acute and chronic disorders of the respiratory tract, particularly in exacerbation chronic bronchitis and asthmatic bronchitis.

Contraindications:

Hypersensitivity to ambroxol.

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Dosage:

TRANSMUCO tablet: Adults and children over 12 years: 1 tablet, 2-3 times daily Children 6-12 years : ½ tablet, 2-3 times daily The tablets should be taken after meals with liquid. TRANSMUCO syrup: 6-12 years : 5 mL, 2-3 times daily 2-6 years : 2,5 mL, 3 times daily Under 2 years: 2,5 mL, 2 times daily

Warning and Precautions:

During pregnancy and lactation ambroxol can be used only if necessary, and the use of ambroxol in such cases still needs more observations. Ambroxol should no?t be used for a long term therapy without any physician consultation. In several renal insufficiency cases, the accumulation of the metabolite of ambroxol in the liver occurred. Skin reactions such as erythema multiforme, Stevens-Johnson Syndrome (SJS)/Toxic epidermal Necrolysis (TEN) and Acute Generalized Exanthematous Pustulosis (AGEP) related to the use of ambroxol have been reported. If symptoms or signs of progressive skin rash occur (sometimes blisters or mucous lesions), ambroxol treatment should be stopped immediately and seek help from health workers.

Adverse events:

- Intolerant reaction after administration of ambroxol has been rarely reported. - Mild gastrointestinal side effects have been reported in a few patients. - Allergic reactions can be occurred in a few cases and such allergic patients also indicated allergy reactions with other drugs. Such reaction that can be found on skin, facial swelling, dyspnea, fever. - There have been no report on the ability to drive and operate machines. - Immune system disorders   Rarely: Hypersensitivity reactions   Unknown: Anaphylactic reactions include anaphylactic shock, angioedema and itching - Skin disorders and subcutaneous tissue   Rarely: Rash, urticaria   Unknown: Severe skin side effects (including erythema multiforme, Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis and Acute Generalized Exanthemous Pustulosis).

Drugs Interaction:

Administration with antibiotics (amoxicillin, cefuroxime, erythromycin, doxicicline) caused increasing the penetration of antibiotics in lung.

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