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AERRANE

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    Komposisi:

    Isoflurane 100%.

    Bentuk sediaan:

    Cairan inhalasi dalam botol kaca 250 mL

    Farmakologi:

    Merupakan anestetik inhalasi berhalogen dengan onset dan pulih sadar yang cepat, bau sedikit tajam, MAC 1,15%, metabolisme di hati sebesar 0,2%, dan relatif stabil terhadap CO2 absorbent.

    Indikasi:

    Induksi dan pemeliharaan anestesi umum pada dewasa dan anak-anak.

    Kontraindikasi:

    • Hipersensitivitas terhadap anestesi halogen. • Diketahui atau dicurigai adanya hipertemia malignant genetic. • Pasien dengan riwayat hipertermia malignan, atau adanya disfungsi hati, ikterik, demam yang tidak diketahui, leukositosis, atau eosinofilia yang terjadi setelah pemberian anestesi halogen. • Operasi obstetrik. • MAOI non-selektif.

     

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    Dosis:

    Induksi anestesi: - Mulai dosis 0,5% lalu dinaikkan secara bertahap. - Dosis 1,3-3,0% dpt menyebabkan anestesi dalam 7-10 menit. Pemeliharan anestesi: - 1,0-2,5% AERRANE + N2O/O2 - 1,5-3,5% AERRANE + O2 100% Pemulihan: - Dosis diturunkan hingga 0,5% saat operasi berakhir s/d 0%

    Peringatan dan Perhatian:

    - Diberikan dengan vaporizer khusus isoflurane. - Isoflurane dapat mempengaruhi pernapasan. - Isoflurane dapat meningkatkan aliran darah otak dan tekanan intrakranial.

    Efek Samping:

    Gangguan saluran cerna, pusing, ruam kulit.

    Interaksi obat:

    • MAOI non-selektif • Beta-simpatomimetik (isoprenaline) dan alfa-beta-simpatomimetik (epinefrin atau adrenalin; norepinefrin atau noradrenalin) • Beta bloker • Isoniazid • Simpatomimetik langsung • Senyawa pelumpuh otot • Morfin • Antagonis kalsium

    AERRANE

     

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    Composition:

    Isoflurane 100%

    Presentation:

    Inhalation liquid in glass bottle 250 mL

    Pharmacology:

    It is a halogen inhalation anesthetic with rapid onset and conscious recovery, smells slightly sharp, MAC 1.15%, metabolism in the liver by 0.2%, and relatively stable against CO2 absorbent.

    Indications:

    Aerrane is a volatile halogenated anaesthetic for general inhalation anaesthesia.

    Contraindications:

    • Hypersensitive to halogenated anaesthetics. • Known or suspected genetic disposition toward malignant hyperthermia. • Patients with a history of malilgnant hyperthermia, or in whom liver dysfunction, jaundice or unexplained fever, leucocytosis, or eosinophilia has ocured after a previous halogenated anaesthetics administration. • Obstetric operation. • Nonselective MAOI.

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    Doses:

    Induction of anaesthesia: • Starting concentration of 0,5%, then raised gradually. • Concentrations of 1,3-3,0% usually bring about surgical anaesthesia within 7 to 10 minutes. Maintenance of anaesthesia: • Anaesthesia can be maintained during surgery using concentration of 1,0-2,5% with the simultaneous administration of N2O and O2. • A higher concentration of 1,5-3,0%of Aerrnae is necessary if Aerrane is administered with pure oxygen. Recovery: • The concentration of Aerrane must be reduced to 0.5% at the end of the operation, or to 0% during closure of the wound to allow prompt recovery.

    Warning and attentions:

    • Aerrane must only be used by a licensed anaesthetist. Since the depth of anaesthesia can change easily and rapidly with Aerrane, only vaporisers that have been specially calibrated for this product may be used. The extent of blood pressure reduction and respiratory depression can be indication of the extent of anaesthesia.

    Side Effects:

    Malignant hyperthermia, arterial hypotension, increase heart rate, respiratory depression, disturbance of the liver function, shivering, nausea, vomiting, pregnancy can give rise to irritationg action on the mucous membrane, increase white blood cell, rash.

    Drug Interactions:

    • Nonselective MAOI • Beta-sympathomimetics (isoprenaline) and alpha- and beta-sympathomimetics (epinephrine or adrenaline; norepinephrine or noradrenaline) • Beta blockers • Isoniazid • Indirect sympathomimetics • Muscle relaxing agents • Morphine analgesics • Calcium antagonists

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