Oleh admin kalbemed pada April 09, 2018 06:00

Metformin Mencegah Komplikasi pada Kehamilan dengan PCOS

Wanita PCOS (polycystic ovary syndrome) mengalami peningkatan risiko menderita komplikasi pada kehamilan. Seperti kita ketahui, metformin merupakan obat diabetes oral yang banyak manfaatnya. Studi berjudul PregMet 2 yang dipresentasikan pada ENDO 2018: The Endocrine Society Annual Meeting memberikan informasi tambahan bahwa metformin dapat memperbaiki outcome wanita dengan sindrom ovari polikista (polycystic ovary syndrome (PCOS)). Sebelumnya telah ada studi yang menilai hal yang sama, namun masih underpowered. Hal tersebut seperti disampaikan oleh Tone Shetelig Løvvik, MD, dari the Norwegian University of Science and Technology, Trondheim.

Pada studi PregMet 2, 487 wanita PCOS dari 14 senter di Norwegia, Swedia, dan Islandia secara acak diberikan metformin (500 mg dua kali sehari pada minggu pertama, 1000 mg dua kali sehari sampai melahirkan) atau plasebo. Rerata usia 30 tahun dan IMT 28 kg/m2 pada kondisi awal.

Hasilnya dari studi tersebut menunjukkan bahwa pada kelompok wanita hamil yang mengkonsumsi metformin selama kehamilan memiliki risiko yang lebih rendah untuk terjadinya keguguran dan kelahiran prematur dibandingkan wanita yang diberikan plasebo. Angka kejadian gabungan late miscarriage dan kehamilan prematur adalah 5% dengan metformin dan 10% dengan plasebo.

Tidak ditemukan adanya perbedaan pada kondisi hipertensi atau pre eklampsia, cara persalinan atau perdarahan pasca persalinan antara pasien yang diberikan metformin versus plasebo. Peningkatan berat badan juga lebih kecil selama kehamilan pada pemberian metformin. Selain itu, bayi yang lahir dari ibu yang mengkonsumsi metformin memiliki lingkar kepala lebih besar namun masih dalam rentang normal. (PMP)
    

Image: Ilustrasi
Referensi: Tucker ME. Metformin may prevent pregnancy complications in PCOS [Internet]. 2018 [cited 2018 March 25]. Available from: https://www.medscape.com/viewarticle/894316.

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