Oleh Admin Kalbe Medical pada February 27, 2018 07:30

Erdosteine Memperbaiki Klinis Pasien Bronkitis Kronik dan PPOK

Stres oksidatif berkontribusi terhadap eksaserbasi penyakit paru obstruktif kronik (PPOK) dan antioksidan dapat menurunkan tingkat eksaserbasi, meskipun data mengenai efek obat ini pada durasi eksaserbasi masih kurang.

Studi RESTORE (Reducing Exacerbations and Symptoms by Treatment with ORal Erdosteine in COPD) merupakan studi acak, tersamar ganda, dengan kontrol plasebo, yang melibatkan pasien berusia 40-80 tahun dengan Global Initiative for Chronic Obstructive Lung Disease stadium II/III. Pasien mendapat erdosteine 300 mg dua kali sehari, atau plasebo, yang ditambahkan pada terapi PPOK selama 12 bulan, dengan outcome utama adalah jumlah eksaserbasi akut selama studi. Pada populasi ITT pre-spesifik dari 445 pasien (74% pria, usia rata-rata 64,8 tahun, dengan volume ekspirasi paksa dalam 1 detik 51,8%, erdosteine menurunkan tingkat eksaserbasi sebesar 19,4% dibanding plasebo, menurunkan tingkat eksaserbasi ringan sebesar 57,1% dibanding plasebo, namun tidak berbeda bermakna pada eksaserbasi berat, meskipun cenderung lebih baik pada erdosteine.

Erdosteine menurunkan durasi eksaserbasi terlepas dari beratnya kejadian sebesar 24,6%, secara bermakna memperbaiki skor keparahan subjektif subjek dan dokter, serta menurunkan penggunaan obat pereda, tetapi tidak mempengaruhi skor St George's Respiratory Questionnaire atau waktu hingga eksaserbasi pertama kali. Pada pasien dengan PPOK, erdosteine dapat menurunkan tingkat dan durasi eksaserbasi. Persentase pasien dengan kejadian yang tidak diharapkan sama pada kelompok erdosteine dan plasebo.

Sebelumnya, suatu meta-analisis menunjukkan bahwa terapi dengan erdosteine dikaitkan dengan perbaikan yang bermakna dan gejala dibandingkan dengan plasebo atau mukolitik lain. Namun, kesimpulan meta-analisis tersebut dikritik karena meta-analisis tersebut tidak mencegah adanya bias seleksi di sepanjang studi. Dengan mempertimbangkan hal tersebut dan publikasi dari dua artikel baru yang berfokus pada pencegahan eksaserbasi penyakit paru obstruktif kronik (PPOK) dengan erdosteine, maka dilakukan sintesis kuantitatif melalui meta-analisis data yang tersedia saat ini mengenai penggunaan obat ini.

Penemuan ini mencakup data dari 10 studi yang melibatkan 1278 pasien dan menunjukkan bahwa erdosteine mampu memperbaiki skor klinis pasien dengan bronkitis kronik dan PPOK, menurunkan risiko keseluruhan eksaserbasi bronkitis kronik/PPOK, dan menurunkan risiko mengalami minimal satu kali eksaserbasi.Lebih lanjut, data juga menunjukkan bahwa erdosteine dapat memperpanjang waktu hingga eksaserbasi PPOK pertama kali, menurunkan durasi eksaserbasi PPOK, dan risiko perawatan di rumah sakit karena PPOK.

Simpulan:
Hasil meta-analisis menunjukkan bahwa erdosteine mampu memperbaiki skor klinis pasien dengan bronkitis kronik dan PPOK, menurunkan risiko keseluruhan eksaserbasi bronkitis kronik/PPOK, dan menurunkan risiko mengalami minimal satu kali eksaserbasi. Erdosteine juga dapat memperpanjang waktu hingga eksaserbasi PPOK pertama kali, menurunkan durasi eksaserbasi PPOK, dan risiko perawatan di rumah sakit karena PPOK. Dengan demikian, erdosteine dapat ditambahkan pada daftar obat yang dapat direkomendasikan untuk mengobati PPOK. (EKM)

Image : Ilustrasi
Referensi:
1.Negro RWD, Wedzicha JA, Iversen M, Fontana G, Page C, Cicero AF, et al. Effect of erdosteine on the rate and duration of COPD exacerbations: The RESTORE study. European Respiratory Journal 2017;50:1700711. DOI: 10.1183/13993003.00711-2017
2.Cazzola M, Calzetta L, Page C, Rogliani P, Matera MG. Impact of erdosteine on chronic bronchitis and COPD: A meta-analysis. Pulm Pharmacol Ther. 2018;48:185-94. doi: 10.1016/ j.pupt.2017.11.009.

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## Max Taranov
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## Max Taranov
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