Oleh admin kalbemed pada February 07, 2018 06:00

Omega-3 Berpotensi Memperbaiki Fungsi Kognitif Lansia

Gangguan kognitif merupakan kondisi yang sering terjadi pada lansia dan makin meningkatkan beban ekonomi seiring dengan bertambahnya usia harapan hidup. Tidak ada terapi farmakologi yang efektif hingga saat ini. Mild cognitive impairment (MCI) merupakan gangguan derajat sedang dari proses penuaan sampai demensia. Dengan meningkatnya persentase lansia, angka kejadian MCI juga meningkat cepat, dan studi sistematik menunjukkan bahwa angka kejadian MCI dari 0,5% sampai 42% di seluruh dunia. Bahkan, individu dengan MCI 10 kali lebih tinggi risikonya untuk menjadi demensia dibandingkan dengan individu yang kognitifnya normal. MCI menjadi derajat penting untuk melakukan intervensi segera terhadap demensia.

Polyunsaturated fatty acids (PUFA) omega-3, khususnya eicosapentaenoic acid (EPA) dan docosahexaenoic acid (DHA), mempunyai peranan untuk melindung terjadinya gangguan kognitif terkait penuaan. Studi PUFA omega-3 pada lanjut usia yang sehat, pasien MCI dan penyakit Alzheimer telah dilakukan, dan hasilnya menunjukkan bahwa pasien dengan MCI responnya lebih baik.

Inflamasi atau peradangan merupakan karakteristik dari banyak penyakit neurodegeneratif, termasuk penyakit penuaan. Hipotesis menyebutkan bahwa pencegahan atau manajemen inflamasi dapat mencegah terjadinya penurunan kognitif pada MCI dan memperlambat terjadinya penyakit penuaan. PUFA omega-3 sebagai anti-inflamasi dan alat yang membantu menyelesaikan masalah perifer. Hal ini telah ditunjukkan potensi modulasi terhadap neuroinflamasi dengan menurunnya produksi EPA dari arachidonic acid, sementara turunan EPA dan DHA terlibat dalam proses resolusi yang berhubungan dengan inflamasi, dan secara aktif menghambat reaksi inflamasi.  

Di Cina dilakukan penelitian dengan tujuan untuk menilai efek suplementasi PUFA omega-3 terhadap fungsi kognitif lansia dengan MCI. Desain dan metodenya adalah dengan mengumpulkan subyek sebanyak 86 individu MCI dengan usia di atas 60 tahun, kemudian diacak menjadi 2 kelompok. Kelompok perlakuan (n=44) mendapatkan PUFA omega 3 (DHA 480 mg dan EPA 720 mg), sedangkan kelompok kontrol (n=42) mendapatkan plasebo. Perubahan fungsi kognitif dinilai dengan menggunakan Basic Cognitive Aptitude Tests (BCAT). Hasilnya menunjukkan pada kelompok perlakuan mengalami perbaikan skor BCAT, kecepatan perseptual, space imagery efficiency, dan memori (p<0,01) dibandingkan dengan kontrol. (LAI)


Image: Ilustrasi
Referensi:
1. Bo Y, Zhang X, Wang Y, You J, Cui H, Zhu Y, et al. The n-3 polyunsaturated fatty acids supplementation improved the cognitive function in the Chinese elderly with mild cognitive impairment: A double-blind Randomized Controlled Trial. Nutrients 2017;9: 54. doi:10.3390/nu9010054.
2. Eshkoor SA, Hamid TA, Mun CY, Ng CK. Mild cognitive impairment and its management in older people. Clin. Interv. Aging 2015;10:687–93.

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## Hilarys Addison
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A portion of the little, here and now, randomized trials of docosahexaenoic corrosive or potentially eicosapentaentoic corrosive supplementation have discovered beneficial outcomes on a few parts of discernment in more seasoned grown-ups who were subjectively in place or had mellow intellectual disability, Animation Video Maker albeit little impact was found in members with Alzheimer's illness. Expansive, long haul trials around there are required.
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## Paul Morrison
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This review accumulates all the most significant late clinical trials on omega-3 supplementation in more seasoned grown-ups. Specifically, we inspected the impacts of omega-3 on various clinical results, in particular, intellectual decay, cardiovascular system, bone wellbeing, muscle execution. The accessible information energizes higher admissions of omega-3 in the eating regimen or particular supplements, however, more investigations are expected to clear up the clashing outcomes in the do my assignment writing on the viability of omega-3 in keeping up bone health.
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