Oleh Admin Kalbe Medical pada November 08, 2017 07:30

Tofacitinib Efektif Memperbaiki Gejala Ulcerative Colitis

Ulcerative colitis adalah salah satu penyakit peradangan kronik yang terjadi pada saluran cerna. Penyakit ini ditandai oleh adanya peradangan dan ulkus pada kolon dan rektum. Gejala yang dialami antara lain nyeri perut, diare, dan BAB berdarah. Ada beberapa teori yang mencoba menjelaskan penyebab dari penyakit ini, tetapi belum ada yang bisa menjelaskan sepenuhnya.

Salah satu teori adalah adanya reaksi autoimun dalam tubuh pasien. Oleh karena itu, pengobatan ulcerative colitis biasanya melibatkan pengobatan antiinflamasi seperti sulfasalazine atau mesalazine, corticosteroid, dan azathioprine. Apabila gagal dengan pengobatan tersebut, maka dapat menggunakan pengobatan anti-TNF misalnya adalimumab atau infliximab.

Salah satu pengobatan baru yang diharapkan dapat efektif untuk ulcerative colitis adalah tofacitinib. Tofacitinib adalah janus kinase inhibitor yang bekerja menghambat reseptor pada pathway janus kinase, sehingga menurunkan reaksi inflamasi sistemik pada ulcerative colitis.

Dr. Panes dan tim dari Eropa dan USA melakukan sebuah uji klinik fase 3 untuk mengetahui apakah penggunaan tofacitinib ini dapat bermanfaat pada pasien dengan ulcerative colitis. Uji klinik ini diberi nama OCTAVE dan dibagi menjadi 2 uji klinik, yaitu OCTAVE 1 dan OCTAVE 2. Pada OCTAVE 1, sebanyak 598 pasien diikutsertakan dan pada OCTAVE 2 sebanyak 541 pasien diikutsertakan. Hasilnya, dari segi skor gejala IBDQ, kelompok tofacitinib mencapai perbaikan skor yang lebih baik dari plasebo; OCTAVE 1 28,9 dan OCTAVE 2 31,5 versus plasebo OCTAVE 1 15,4 dan 17,2; P<0,0001.

Kesimpulan:
Pada pasien ulcerative colitis yang tidak membaik dengan pengobatan standar (sulfasalazine, mesalazine, azathioprine), penggunaan tofacitinib dapat bermanfaat untuk memperbaiki gejala secara bermakna. (NNO)

Image : Ilustrasi
Referensi:
1.Garud S, Peppercorn MA. Ulcerative colitis: Current treatment strategies and future prospects. Ther Adv Gastroenterol. 2009;2(2):99–108.
2.Panés J, Vermeire S, Lindsay JO, Sands BE, Su C, Friedman G, et al. Tofacitinib in patients with ulcerative colitis: Health-related quality of life in phase 3 randomized controlled induction and maintenance studies. J Crohns Colitis. 2017 Sep 27;

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Comments

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## Taylor Wilson
Wednesday, November 08, 2017 6:34 PM
I have to write an article on Ulcerative colitis for Paper Writing Companies and your post helped me a lot, I just have to conform is that true? "Ulcerative colitis is a chronic inflammatory disease that occurs in the gastrointestinal tract".
Nida Amber
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Friday, November 10, 2017 7:15 PM
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Saturday, November 11, 2017 2:09 PM
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