Oleh Admin Kalbe Medical pada October 02, 2017 07:30

Risiko DM pada Wanita dengan PCOS

Diperkirakan di AS hampir terdapat 6 juta wanita dengan polycystic ovary syndrome/PCOS. Banyak wanita dengan PCOS yang mengalami obesitas, namun risiko munculnya diabetes pada PCOS masih belum diketahui. Wanita dengan PCOS memiliki peningkatan risiko signifikan menderita diabetes tipe 2 pada usia lebih muda dibandingkan kontrol. Hasil studi tersebut adalah berdasarkan studi Denmark berbasis data national registry. Seperti diketahui bahwa PCOS terkait dengan resistensi insulin.
   
Dengan median follow up selama 11 tahun, risiko menderita diabetes adalah 4 kali lipat lebih tinggi (hazard ratio [HR], 4,0; P <0,001) pada wanita PCOS, seperti disampaikan oleh associate professor dan kolega di University of Southern Denmark di Odense. Angka kejadian DM tipe 2 juga 4 kali lipat lebih tinggi pada pasien dengan PCOS dibandingkan kontrol (8,0 per 1000 pasien-tahun vs 2,0 per 1000 pasien-tahun, p <0,001). Studi ini dipublikasikan secara online pada Journal of Clinical Endocrinology & Metabolism. Ditemukan rerata usia pasien yang didiagnosis DM tipe 2 dengan PCOS berada di usia 31 tahun (82% berusia <40 tahun) dan 35 tahun pada mereka tanpa PCOS (66% dari mereka <40 tahun) dengan p<0,01.


Semakin banyak jumlah kehamilan maka risiko menderita DM tipe 2 akan lebih rendah di antara wanita dengan PCOS. Kehamilan multipel mengindikasikan fenotip PCOS yang kurang berat sehingga juga akan menurunkan risiko munculnya DM tipe 2. Diperlukan studi di masa yang akan datang untuk mengevaluasi efek dari kontrasepsi oral dan seberapa banyak jumlah kelahiran yang berisiko menderita DM tipe 2 pada wanita PCOS.

   
Dengan adanya hasil studi ini memberikan makna yang sangat penting karena diabetes dapat muncul pada usia muda dan produktif. Dengan demikian, sangat penting dilakukan skrining akan munculnya diabetes ini. Prediktor paling baik untuk DM tipe 2 pada PCOS adalah indeks massa tubuh (IMT) dan glukosa darah puasa. Namun, HbA1c, GD2PP, resistensi insulin, dan trigliserida juga prediktif untuk diagnosis DM tipe 2 di masa yang akan datang. (PMD)


Image : Ilustrasi
Referensi:
1.Jenkins K. Risk of diabetes at early age quadrupled in women with PCOS [Internet]. 2017 [cited 2017 Sept 11]. Available from: http://www.medscape.com/viewarticle/885421#vp_1
2.Rubin KH, Glintborg D, Nybo M, Abrahamsen B, Andersen M. Development and risk factors of type 2 diabetes in a nationwide population of women with polycystic ovary syndrome. The Journal of Clinical Endocrinology & Metabolism. jc.2017-01354. https://doi.org/10.1210/jc.2017-01354

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