Oleh Admin Kalbe Medical pada March 14, 2017 07:30

Asupan Zinc yang Rendah Berkaitan dengan Meningkatnya Kejadian Depresi

Zinc adalah mikronutrien essensial yang memiliki beberapa peran pada metabolisme tubuh manusia, seperti sistem imun, metabolisme, dan inflamasi. Defisiensi zinc menjadi salah satu faktor risiko diabetes dan juga rheumatoid arthritis. Zinc menjadi penting karena menjadi kofaktor pada berbagai jenis enzim yang berfungsi pada produksi ataupun netralisasi reactive oxygen species (ROS). Pada pasien yang mengalami defisiensi zinc, terjadi penurunan netralisasi ROS, sehingga berakibat meningkatnya kadar ROS.

Tidak hanya pada sistem antioksidan, zinc juga berperan pada keseimbangan kadar neurotrasmiter di susunan saraf pusat, sehingga diduga kadar zinc yang lebih rendah dapat berkaitan dengan kejadian depresi. Pernah ada beberapa penelitian yang mengevaluasi kaitan kadar zinc terhadap kejadian depresi, dengan hasil yang bervariasi. Oleh karena itu, dr. Li dan tim dari RRC melakukan sebuah meta-analisis yang diterbitkan di jurnal Psychiatry Research bulan Februari tahun 2017.

 
Metaanalisis ini mengevaluasi hubungan antara asupan zinc, serta asupan zat besi dengan kejadian depresi. Metaanalisis ini mengevaluasi data dari 12 penelitian, 9 penelitian dari zinc dan 3 penelitian zat besi. Hasilnya dirangkum dengan angka RR (relative risk) kejadian depresi pada kelompok asupan zinc yang tinggi dengan kelompok dengan asupan zinc yang rendah, serta angka RR (relative risk) kejadian depresi pada kelompok asupan zat besi yang tinggi dengan kelompok dengan asupan zat besi yang rendah.


Hasilnya didapatkan terdapat kaitan yang bermakna antara asupan zinc serta zat besi terhadap kejadian depresi, di mana RR masing-masing adalah 0,67 (95% CI: 0,58 s/d 0,76) dan 0,57 (95% CI: 0,34 s/d 0,95). Dengan demikian, disimpulkan bahwa individu dengan asupan zinc yang tinggi serta individu dengan asupan zat besi yang tinggi, lebih jarang mengalami depresi.


Kesimpulan:
Dari meta-analisis ini, disimpulkan bahwa individu dengan asupan zinc yang rendah berkaitan dengan kejadian depresi yang lebih tinggi dibandingkan dengan individu dengan asupan zinc yang tinggi. (NNO)

Image : Ilustrasi
Referensi:
1.Zinc: An essential micronutrient - American Family Physician [Internet]. [cited 2017 Feb 26]. Available from: http://www.aafp.org/afp/2009/0501/p768.html
2.Li Z, Li B, Song X, Zhang D. Dietary zinc and iron intake and risk of depression: A meta-analysis. Psychiatry Res. 2017;251:41–7.

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