Oleh Admin Kalbe Medical pada February 10, 2017 07:30

Manfaat PUFA Omega-3 pada Luka Bakar

Selain kasus kritis, pasien luka bakar mayor juga dikarakteristikkan dengan respons inflamasi yang memanjang. Injuri termal yang berat juga dihubungkan dengan meningkatnya kejadian infeksi, yang selalu dihubungkan dengan meningkatnya morbiditas dan mortalitas. Terapi nutrisi termasuk lemak sangat dibutuhkan untuk harapan hidup pasien. Meskipun sampai saat ini lemak masih dianggap eksklusif sebagai sumber energi, beberapa asam lemak, khususnya PUFA omega-3, eicosapentaenoic acid (EPA) dan docosahexaenoic (DHA) mempunyai peranan dalam pengaturan, khususnya berpengaruh terhadap struktur dan fungsi membran sel, metabolisme eikosanoid, produksi sitokin dan interaksi dalam mengatur respons imun inflamasi. Selain itu, juga pernah disebutkan bahwa tingginya dosis asupan lemak (≥ 35% energi total) meningkatkan komplikasi infeksi, akan tetapi pemberian PUFA omega-3 justru menurunkan komplikasi infeksi.

Dari literatur disebutkan bahwa dengan menambahkan PUFA omega-3 ke dalam formula enteral yang dikombinasi dengan nutrien imunomodulasi seperti arginin, glutamin, nukleotida, antioksidan, dan vitamin E, akan semakin menurunkan komplikasi infeksi yang disebabkan karena luka bakar. Akan tetapi, kombinasi berbagai macam komposisi tersebut membuat susah untuk diidentifikasi efek mana yang mempunyai peranan penting dalam luka bakar.

Efek PUFA omega-3 terhadap respons inflamasi telah diketahui, dan pada pasien luka bakar khas dengan inflamasi yang memanjang. Oleh karena itu, dilakukan penelitian apakah PUFA omega-3 dapat menurunkan komplikasi infeksi pada luka bakar. Desain penelitiannya adalah prospektif, acak, tersamar. Metodenya dengan mengumpulkan subjek luka bakar yang dirawat di ICU dengan luas luka bakarnya >15% body surface area (BSA), menggunakan ventilator selama >6 hari dan mendapatkan nutrisi enteral. Total subjek yang memenuhi kriteria 92 kemudian dibagi menjadi 2 kelompok secara acak, yaitu kelompok perlakuan mendapatkan nutrisi enteral yang ditambahkan dengan 50% lemak yang berasal dari fish oil (n=47) dan kelompok kontrol hanya mendapatkan nutrisi enteral standar saja (n=45). Kemudian parameter dinilai sebelum dan sesudah pemberian, yang dinilai adalah komplikasi infeksi (kejadian sepsis berat dan syok sepsis), residu lambung, lamanya penggunaan ventilator, dan mortalitas.

Hasilnya menunjukkan pada kelompok perlakuan terjadi penurunan yang bermakna terhadap terjadinya komplikasi infeksi (p=0,03) dan residu lambung (p<0,03). Akan tetapi, penggunaan ventilator dan mortalitas tidak ada perbedaan yang bermakna secara statistik. Dari penelitian dapat disimpulkan bahwa pemberian nutrisi enteral yang ditambahkan dengan 50% PUFA omega-3 dapat menurunkan komplikasi infeksi dan residu lambung, akan tetapi tidak berpengaruh terhadap mortalitas. (LAI)

Image : Ilustrasi
Referensi:
1.Serrana T, Estrella E. Effect of omega 3 polyunsaturated fatty acids derived from fish oil in major burn patients: A prospective randomized controlled pilot trial. Clinical Nutrition 2017;1:6.
2.Calder PC. Omega-3 polyunsaturated fatty acids and inflammatory processes: Nutrition or pharmacology? Br J Clin Pharmacol. 2013;75:645-62.

Related Articles

Astaxanthin Melindungi Kulit dari Photoaging akibat UVA Hasil suatu studi baru pada hewan di Jepang menunjukkan bahwa suplementasi makanan dengan astaxanthin dapat melindungi kulit dari efek buruk radiasi U...
Kombinasi Pioglitazone dan Asam Lemak Omega-3 pada Pasien DM Obesitas Tatalaksana bagi penderita diabetes tidak hanya bersifat farmakologis, namun juga dengan modifikasi gaya hidup seperti intervensi terhadap makanan yan...
Dampak Terapi NSAID plus SGLT-2 Inhibitor terhadap Fungsi Ginjal Pasien Diabetes FDA AS telah meminta kepada farmasi yang memasarkan obat diabetes oral dari generasi terbaru, yaitu sodium-glucose cotransporter 2 (SGLT2) inhibitor, ...
Pemantauan Proteinuria pada Pasien Thalasemia Beta dengan Deferasirox Terapi iron chelation merupakan salah satu tatalaksana thalasemia beta. Deferasirox termasuk iron chelator poten dan diterima sebagai lini pertama ter...
Kadar Vitamin D Tinggi Membantu Memperlambat Penuaan Defisiensi vitamin D telah dikaitkan dengan mortalitas dari semua penyebab dan kanker. Para ilmuwan dari Inggris juga menemukan bahwa kadar vitamin D ...

Comments

joeychen joeychen
## joeychen joeychen
Friday, February 10, 2017 1:01 PM
Michael Kors in this colorful spring Savannah launched a new series of mulberry replica handbags, simple design classic, Morocco cross pattern leather texture luxurious and practical, is the undisputed representative of Jetset style. Savannah series of two different size bags for the day with the possibility to create more. Color pink makes air is filled with the sweet breath, return to simple romance. Clothing line with simple white color, lightweight fabric with a soft romantic lace and encrusted exquisite embroidery denim-based, to create simple white female romantic style. Whether white crochet tops, casual Slim swing dress, also, or sweet and sexy strapless suits, simple but full of ingenuity to create a sense of design. Mesh sweater and chic, delicate embroidery and lace soft, fine texture and edge wear design for your wardrobe and add a touch of pure chic. This series of replica handbags thong footwear, romantic love lovely colors to easily interpret the girls. The patent leather open-toed heels nude color, soft colors like first love hazy. "First Love" series launched Delray watches, fine Rihui pattern dial uphold minimalist, acetate fiber material not only reduces the weight of the watch itself, so that the wrist more agile and colorful spring colors more revealing flashy charm. Metal strap sprinkled different colors of imitation marble block edge of the dial set with two rows of exquisite small drill, with tranquil color tones mainly for girls wrists add a little love in the air. Accessories also fully embodies the "first love" series of style, Blush Rush series let rose pink crystal stone and mint green amazonite considerably. Pave details personalized unrestrained pyramid element adds a little femininity. Ring in the form of louis vuitton replica a pair, both rose rouge stone ring face, there are dotted with exquisite ring surface of diamond chips.
wq123 wq123
## wq123 wq123
Wednesday, February 22, 2017 8:50 AM

Recently, true religion jeans men the thomas sabo uk leisure michael kors purses time nike shoes once burberry handbags outlet again true religion jeans outlet holding christian louboutin uk Mr. versace outlet Lu montre homme Xun's barbour jackets "set", rolex which salomon schuhe one longchamp of the north face the marc by marc jacobs "July kate spade 16 abercrombie and fitch kids in replica rolex Guangzhou retro jordans know longchamp outlet middle nike huarache school abercrombie [2] soccer shoes outlet speak" jaguars jerseys impressed, uggs canada feel tommy hilfiger a air max lot, abercrombie.com some long champ of polo outlet online the wedding dress original fivefingers excerpts oakley sunglasses are barbour jacket outlet as patriots jerseys follows:

"Speaking nike roshe run of adidas sneakers reading, vikings jerseys it ray ban uk seems uggs outlet very nike running shoes understandable cavaliers jersey thing, michael kors as ray ban outlet long prada handbags as michael kors outlet the pandora canada book new balance is cheap shoes to uggs on sale read puma online shop it, ray ban wayfarer but adidas yeezy shoes not bengals jerseys so toms shoes outlet simple. moncler mens jackets At ralph lauren outlet online least, true religion there mbt womens shoes are los angeles lakers two: azcardinals jerseys First, nike air max professional barbour mens jackets reading, mcm handbags one cheap jerseys is nike air max thea the nike air force hobby detroit pistons reading. valentino outlet , relojes For burberry outlet store example, coach black friday students lacoste shirts because hollister online of cheap basketball shoes school, uggs outlet the nba jerseys teacher nike air max because oakley sunglasses outlet of jimmy choo outlet homework, burberry online shop do levis jeans not ugg australia turn ugg australia the pandora jewellery australia book, ralph lauren outlet there barbour jackets are chiefs jerseys some north face jackets dangerous toms shoes outlet is michael kors australia that the north face outlet I philipp plein clothing want rayban to prada shoes sit swarovski jewelry among northface the michael kors outlet online princes nike roshe run must new balance outlet be michael kors bags some suns jersey of memphis grizzlies jersey this nike store experience, oakley sunglasses some ugg australia do cheap oakley not oakley like nike store uk arithmetic, ralph lauren factory store and tory burch sandals some north face do air max not ugg boots like uggs black friday the polo ralph lauren outlet museum, true religion jeans women But michael kors handbags have oakley sunglasses to rolex replica learn, celine outlet otherwise, nike air huarache can rams jerseys not air max graduate, insanity workout calendar can polo ralph lauren not womens clothing go iphone 4s cases to nike soccer shoes school, ipad mini cases and uhren shop the adidas future steelers jerseys of longchamp life fendi will hermes outlet have ray ban pas cher hindered red bottom the burberry outlet online ... eagles jerseys ... vans shoes "

It ugg australia seems michael kors outlet that toms shoes outlet 88 michael jordan years chi hair ago, ralph lauren online shop Lu veneta Xun, michael kors outlet well michael kors outlet online sale versed adidas zx flux in gooses reading giuseppe zanotti sneakers the cheap michael kors pain rayban of rayban professional nike factory books ray ban sunglasses - polo ralph lauren outlet online in nike schoenen order air jordan shoes to burberry outlet store survive, converse shoes in easton bats order dolphins jerseys to coach outlet online make burberry a michaelkors.com living, nike tn many longchamp outlet people cheap nfl jerseys in minnesota timberwolves jersey a chargers jerseys lot purses and handbags of hilfiger online shop time, dre beats had ray ban sunglasses outlet to abercrombie kids put ghd down lac jersey their hollisterco hobbies burberry outlet and orlando magic jersey hard hollister co to red bottom read nba jerseys some polo outlet career-related beats audio reference michael kors books. cheap oakley sunglasses Because new balance it buccaneers jerseys is asics boring air max 2014 and polo ralph lauren tasteless, adidas online shop it adidas.se really warriors jerseys teaches ray bans people ralph lauren to airmax suffer.

Perhaps tory burch sandals Mr. polo outlet store Lu cheap oakley sunglasses Xun rolex watches did nike free 5.0 not burberry outlet online know beats by dre headphones that celine outlet after bills jerseys 88 timberland years nike running of eyeglasses stores the colts jerseys day, ray ban outlet the lunette ray ban pain barbour womens jackets of roshes reading 76ers jerseys is coach factory online actually oakley frogskins no coach factory outlet online qualitative polo ralph lauren change toronto raptors jersey - burberry outlet store in easton bats the new orleans pelicans jersey "progress true religion outlet of kate spade handbags people jordans for sale progress, stephen curry shoes backward nj jerseys people cowboys jerseys fail" ralph lauren outlet online competition toms outlet online era, michael kors many texans jerseys people timberland outlet still burberry sale for cheap jerseys the cheap jerseys sake reebok of longchamp handbags life hermes birkin bag Had instyler ionic styler to coach usa give bottega veneta up roshe run their adidas shoes favorite nike fu?ballschuhe casual www.tommyhilfiger.nl book.

Rolling ray ban occhiali the packers jerseys Red, prada the utah jazz jersey mortal vans schuhe beings, longchamp handbags in oakley sunglasses order swarovski crystal to cheap ray ban feed louboutin their chi flat iron families ugg or coach factory outlet online to cheap oakley sunglasses win milwaukee bucks jersey more adidas superstar fame, oakley desperately ray ban zonnebril reading, red bottom shoes learning, chrome hearts rings in nfl jerseys order puma shoes outlet to converse outlet have ugg boots a burberry glorious prada tracksuits future, purses and handbags this new balance is ferragamo nothing air jordan retro wrong, michael kors uhren but oakley sunglasses the coach bags outlet utilitarian nike blazers reading tory burch handbags is swarovski online shop actually ny jersey teaching michael kors people bcbg max azria pain.

This burberry outlet online is coach outlet online not hermes belt to mcm backpack remind toms shoes me indiana pacers jersey of lions jerseys more portland trail blazers jersey than north face canada 20 air max thea years burberry ago, michael kors v?skor when coach outlet online the ravens jerseys practice jordan shoes of michael kors outlet "certified hugo boss outlet online public okc jerseys accountants" nike roshe run is calvin klein outlet hot, cheap jerseys if air max 90 fortunate nike.com enough jets jerseys to montblanc get, miami heat most kate spade bags likely mizuno running shoes by nike mercurial vapor those toms shoes outlet listed michael kors companies swarovski hire, michael kors receive tommy hilfiger canada high nike.se wages, juicy couture outlet or coach black friday by polo ralph lauren some atlanta hawks jerseys people jordan shoes in michael kors bags need bcbg max of hogan sito ufficiale such oakley sunglasses talent prada outlet The adidas superstar local juicy couture government oakley outlet recruitment givenchy shoes outlet and saints jerseys transferred tory burch to hollisterco the oakley financial replica watches system, nike air max eat seahawks jerseys the abercrombie and fitch financial new balance shoes savings burberry sale of prada outlet drought bears jerseys and denver nuggets jerseys water. abercrombie and fitch This coach outlet sale rare ralph lauren opportunity, hilfiger outlet of the north face course, coach outlet attracted nike running shoes my tommy hilfiger outlet attention omega watches in ray ban outlet the 49ers jerseys Finance converse chucks Bureau nike.dk of panthers jerseys the nike roshe run accounting jordan retro unit thomas sabo of celtics jersey the mavericks jerseys fourth mcm handbags brother, pandora actively guess bags for ralph lauren polo my pandora bracelet registration, ugg australia evidence, nike free and abercrombie do nike air max not ugg boots hesitate michael kors outlet online to tommy hilfiger online order timberland outlet more uggs sets michael kors black friday of nike air max professional ferragamo shoes books converse sneakers to longchamp taschen me, louboutin shoes and dre headphones I sacramento kings finally hollister failed houston rockets to washington wizards jersey live nike huarache up ugg boots to salvatore ferragamo his coach purses outlet expectations, woolrich womens jackets failure replica watches The nfl jerseys reason hogan is toms.com about spurs jerseys two: vans outlet First, pandora charms at cheap nike shoes that mcm bags time michael kors handbags is oakley sunglasses cheap very ray ban wayfarer satisfied babyliss flat iron with michael kors the designer handbags status falcons jerseys quo, p90x3 lack pandora charms of nfl jerseys motivation; redskins jerseys Second, michael kors outlet those oakley sunglasses cheap who ralph lauren black friday are ed hardy clothing not coach bags outlet interested ralph lauren in cheap jerseys those handbags outlet professional christian louboutin books, coach bags outlet and swarovski crystal even broncos jerseys to titans jerseys the replica watches eve sunglasses for women of supra footwear the asics gel exam, browns jerseys or north face outlet even ray bans failed zapatillas nike to dsquared2 outlet read swarovski australia the raiders jerseys book nike store again.

gafas oakley coach outlet bulls jerseys ugg jimmy choo michael kors handbags armani outlet online mcm handbags giants jerseys michael kors uk toms outlet michael kors handbags kate spade ralph lauren polo north face backpacks hornets jersey nike air max ray ban sunglasses north face jackets true religion outlet rolex watches oakley sunglasses outlet ray-ban sunglasses marc by marc jacobs canada gooses giuseppe zanotti hollister clothing moncler women jackets timberland boots

Post Comment

Only registered users may post comments.