Oleh Admin Kalbe Medical pada February 09, 2017 07:30

Hydroquinone 4% Efektif untuk Mencerahkan Hiperpigmentasi Periorbital

Hiperpigmentasi adalah produksi pigmen melanin yang berlebihan oleh sel-sel melanosit pada epidermis. Ada beberapa jenis hiperpigmentasi, misalnya hiperpigmentasi pasca-inflamasi atau hiperpigmentasi periorbital. Pada hiperpigmentasi periorbital, terjadi warna kehitaman gelap di sekitar kedua mata. Hiperpigmentasi periorbital banyak terjadi pada orang-orang di daerah Mediterranea serta orang yang berkulit gelap. Selain itu, pada pasien dengan riwayat alergi, sering juga terjadi hiperpigmentasi periorbital yang dikenal dengan istilah allergic shiner.

Yang menjadi masalah dari hiperpigmentasi periorbital adalah warna hitamnya relatif sulit untuk dicerahkan dibandingkan dengan hiperpigmentasi pasca-inflamasi. Ada beberapa alternatif yang dapat menjadi pilihan, seperti hydroquinone atau asam salisilat. Dr. Ranjan dan tim dari India melakukan sebuah uji klinik yang diterbitkan di Indian Journal of Dermatology tahun 2016. Pada uji klinik ini sebanyak 50 orang dengan hiperpigmentasi periorbital diacak untuk dioleskan obat topikal antara hydroquinone 4% atau asam salisilat 30% selama 12 minggu. Pasien kemudian dinilai secara visual pada minggu ke-4, ke-6, dan ke-12.


Hasilnya, didapatkan perbaikan hiperpigmentasi periorbital apabila diukur dengan menggunakan visual analog scale pada minggu ke-12, pada kedua kelompok. Tidak didapatkan perbedaan efektivitas antara hydroquinone 4% dengan asam salisilat 30%.2


Kesimpulan:
Pada pasien hiperpigmentasi periorbital, penggunaan obat topikal hydroquinone 4% atau asam salisilat 30% efektif untuk mencerahkan, diukur menggunakan visual analog scale. (NNO)

Image : Ilustrasi
Referensi:
1.Sheth PB, Shah HA, Dave JN. Periorbital hyperpigmentation: A study of its prevalence, common causative factors and its association with personal habits and other disorders. Indian J Dermatol. 2014;59(2):151–7.
2.Ranjan R, Sarkar R, Garg VK, Gupta T. A comparative study of two modalities, 4% hydroquinone versus 30% salicylic acid in periorbital hyperpigmentation and assessment of quality of life before and after treatment. Indian J Dermatol. 2016;61(4):413–7.

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