Oleh Admin Kalbe Medical pada January 12, 2017 07:30

Obat Antisense Inhibitor sebagai Obat Penurun Trigliserida

Volanesorsen (sebelumnya dikenal dengan ISIS-APOCIIIRx) adalah suatu obat antisense yang dibuat untuk menurunkan kadar trigliserida dengan menargetkan pada apolipoprotein C-III. Telah diumumkan suatu uji klinik fase 3 berjudul COMPASS, yang memberikan hasil bahwa volanesorsen berhasil mencapai keluaran akhir primernya, yaitu berupa penurunan rerata trigliserida secara signifikan pada pasien yang mengidap hipertrigliseridemia berat.
   
Obat tersebut dikembangkan untuk merawat pasien dengan penyakit metabolik FCS yang jarang dan lipodistrofi parsial familial. Disebutkan bahwa terapi volanesorsen pada 75 pasien menghasilkan penurunan rerata 71,2% dari basal setelah 13 minggu terapi (p <0,0001). Mereka mewakili penurunan absolut dari 869 mg/dL pada pasien yang mengikuti studi dengan rerata kadar trigliserida sebesar 1261 mg/dL. Pasien yang diberikan plasebo hanya mengalami penurunan sebesar 0,9% (pada 38 orang pasien).

   
Selain itu, disebutkan bahwa terdapat 5 orang pasien dengan kondisi familial chylomicronemia syndrome (FCS), dan bagi pasien yang diberikan volanesorsen mengalami penurunan kadar trigliserida sebesar 73% dari basal setelah diberikan terapi selama 13 minggu. Nilai tersebut mewakili penurunan absolut sebesar 1511 mg/dL untuk pasien yang masuk studi dengan kadar trigliserida awal sebesar 2280 mg/dL. Sedangkan dengan pemberian plasebo terhadap 2 pasien, justru terjadi peningkatan rerata sebesar 70%.

   
Secara umum, sebagian besar pasien yang diberikan volanesorsen (82%) mencapai kadar trigliserida sampai di bawah 500 mg/dL setelah terapi 13 minggu, dibandingkan 14% pasien yang dirawat dengan plasebo (p <0,0001). Reaksi di tempat injeksi merupakan kejadian tidak diinginkan yang paling sering terjadi pada pasien yang diberikan volanesorsen, dengan 13% pasien di antaranya terpaksa berhenti dari studi akibat kondisi tersebut. Sedangkan 7% pasien berhenti dari studi akibat kejadian tidak diinginkan yang tidak serius, dan tidak ada pasien yang meninggal selama studi berlangsung.

   
COMPASS merupakan salah satu dari 4 uji klinik global dalam program fase 3 volanesorsen. Perusahaan yang mengembangkan obat ini berencana akan mendapatkan hasil dari uji klinik lainnya di tahun 2017 dan 2019. (PMD)


Image : Ilustrasi
Referensi:
1.Hand L. Triglycerides fall in phase 3 trial of novel antisense inhibitor [Internet]. 2016 [cited 2016 Dec 29]. Available from: http://www.medscape.com/viewarticle/873454.
2.Hand L. Novel antisense inhibitors cut Lp(a) levels in small phase 2 studies [Internet]. 2016 [cited 2016 Dec 29]. Available from: http://www.medscape.com/viewarticle/869475.

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