Oleh Admin Kalbe Medical pada December 29, 2016 08:00

Dampak Berhenti Merokok terhadap Faktor Risiko Kardiovaskular

Merokok adalah salah satu kebiasaan buruk yang sangat merugikan kesehatan karena berkaitan dengan banyak penyakit degeneratif seperti penyakit jantung koroner, penyakit paru obstruktif kronik, dan tromboangitis obliterans. Akan tetapi, banyak orang yang sulit berhenti merokok karena efek adiksi dari nikotin. Oleh karena itu, muncul beberapa obat ynag digunakan untuk membantu pasien agar dapat berhenti merokok, contohnya nicotine replacement therapy.

Merokok adalah salah satu faktor risiko dari penyakit kardiovaskular melalui peningkatan dari marker inflamasi yang berdampak buruk terhadap kardiovaskular antara lain: C-reactive protein, D-dimer, fibrinogen, urinary F2 isoprostane:creatinine [F2:Cr] ratio, white blood cell [WBC] count, dan myeloperoxidase. Berdasarkan hal ini, dr. King dan tim ingin mengetahui manfaat dari berhenti merokok apakah dapat memperbaiki 6 marker inflamasi tersebut. Oleh karena itu, peneliti melakukan sebuah penelitian kohort yang diterbitkan di jurnal Arteriosclerosis, Thrombosis, and Vascular Biology tahun 2016.


Para peneliti mengambil sampel darah dari pasien yang akan menjalani usaha berhenti merokok, mengukur kadar 6 marker inflamasi, kemudian mem-follow up mereka selama 1 tahun, kemudian setelah selesai pengobatan, mengambil darah lagi, mengukur kadar 6 marker inflamasi lagi, lalu membandingkan dengan kadarnya sebelum pengobatan. Hasilnya ternyata, setelah 1 tahun berhenti merokok didapatkan perbaikan kadar dari 2 marker inflamasi, yaitu: F2:Cr ratio (P<0,001) dan WBC counts (P<0,001).


Kesimpulan:
Berhenti merokok berdampak positif berupa penurunan kadar pada 2 marker inflamasi yang menjadi faktor risiko kardiovaskular, yaitu rasio urinary F2 isoprostane:creatinine [F2:Cr] dan hitung sel darah putih. (NNO)

Image : Ilustrasi
Referensi:
1.Nicotine addiction treatment & management: Approach considerations, counseling, nicotine replacement therapy [Internet]. 2016 Oct 28 [cited 2016 Dec 25]. Available from: http://emedicine.medscape.com/article/287555-treatment?pa=zg%2BBbE5Sh1CCj9WzjN1S7ReMYIYFhUGmayhK9BIzeih1pThq6ojTc0pKj7FQ%2BeU8uTRqQxidkpP%2FiIJ5YwNowV%2FDMAtBBAsM6eN9kpLn%2Fas%3D
2.King CC, Piper ME, Gepner AD, Fiore MC, Baker TB, Stein JH. Longitudinal impact of smoking and smoking cessation on inflammatory markers of cardiovascular disease risk. Arterioscler Thromb Vasc Biol. 2016 Jan 1;ATVBAHA.116.308728.

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